Ttr transthyretin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ttrprovided by RGD
Official Full Name: transthyretinprovided by RGD
Primary source: RGD:3916
See related: Ensembl:ENSRNOG00000016275 AllianceGenome:RGD:3916
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TT; Lr1; Tbpa
Summary: Enables hormone binding activity. Predicted to be involved in purine nucleobase metabolic process. Located in extracellular space. Part of protein-containing complex. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 51028.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (12216684..12225972)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (11941791..11951008)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (15532963..15542180, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy.
Title: A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy.
Data suggest that the mutated transthyretin (TTR) seems to have potential as biomarker for early detection of hepatocellular carcinoma (HCC).
Title: Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
Serum transthyretin level dramatically decreased in animals displaying decompression sickness symptoms.
Title: Effect of simulated air dive and decompression sickness on the plasma proteome of rats.
We conclude that stress upregulates TTR expression in choroid plexus.
Title: Stress and glucocorticoids increase transthyretin expression in rat choroid plexus via mineralocorticoid and glucocorticoid receptors.
Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH.
Title: Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model.
Data demonstrate that, in vitro and in vivo, transthyretin is up-regulated by progesterone, and suggest that this response is mediated through a progesterone receptor-mediated mechanism.
Title: Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor.
rat and murine TTR have a lower intrinsic beta-aggregation propensity and a similar native beta-structure stability compared with human TTR.
Title: Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses.
Results suggest that transthyretin is up-regulated by estradiol via a pathway involving estrogen receptors alpha and beta.
Title: 17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway.
The expression of transthyretin in brain of a transgenic mouse model of Alzheimer's disease is asymmetric and affected by age and sex.
Title: Asymmetric expression patterns of brain transthyretin in normal mice and a transgenic mouse model of Alzheimer's disease.
Transthyretin is expressed in the pineal gland >30-fold higher than the median expression level in other tissues, at levels similar to those in the choroid plexus.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Mit1 (e-PCR), detects polymorphism
- UniSTS:119333

RH124760 (e-PCR)
- UniSTS:161582

D18Wox7 (e-PCR)
- UniSTS:118106

PMC164851P1 (e-PCR)
- UniSTS:271521

RH94739 (e-PCR)
- UniSTS:119986

D18Chm93 (e-PCR)
- UniSTS:518323

D18Arb1 (e-PCR)
- UniSTS:240313

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables thyroid hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid hormone binding	IEA Inferred from Electronic Annotation more info
enables thyroid hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in purine nucleobase metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transthyretin

Names: prealbumin, amyloidosis type I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.