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    PCOLCE2 procollagen C-endopeptidase enhancer 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684050, updated on 19-May-2024

    Summary

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    Official Symbol
    PCOLCE2provided by RGD
    Official Full Name
    procollagen C-endopeptidase enhancer 2provided by RGD
    Primary source
    RGD:1595195
    See related
    Ensembl:ENSRNOG00000046848 AllianceGenome:RGD:1595195
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable collagen binding activity; heparin binding activity; and peptidase activator activity. Predicted to be involved in positive regulation of peptidase activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in extracellular region. Orthologous to human PCOLCE2 (procollagen C-endopeptidase enhancer 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 137.5), Muscle (RPKM 122.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See PCOLCE2 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105073086..105130725)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96193461..96251116)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (103459219..103484557)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094231 Neighboring gene progestin and adipoQ receptor family member 9 Neighboring gene inosine triphosphatase, pseudogene 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene uncharacterized LOC120094233 Neighboring gene plastin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. Steiglitz BM, et al. J Biol Chem, 2002 Dec 20. PMID 12393877
    2. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187469

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    procollagen C-endopeptidase enhancer 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127640.1 → NP_001121112.1  procollagen C-endopeptidase enhancer 2 precursor

      See identical proteins and their annotated locations for NP_001121112.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161891
      UniProtKB/TrEMBL
      B1WBU3, M0RD26
      Related
      ENSRNOP00000067519.3, ENSRNOT00000074047.3
      Conserved Domains (3) summary
      cd00041
      Location:32 → 142
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd03576
      Location:291 → 414
      NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...
      pfam00431
      Location:153 → 264
      CUB; CUB domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      105073086..105130725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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