Plp1 proteolipid protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plp1provided by RGD
Official Full Name: proteolipid protein 1provided by RGD
Primary source: RGD:3354
See related: Ensembl:ENSRNOG00000002419 AllianceGenome:RGD:3354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Plp
Summary: A structural constituent of myelin sheath. Involved in several processes, including AMPA selective glutamate receptor signaling pathway; nervous system development; and positive regulation of calcium ion transmembrane transport. Located in myelin sheath. Part of integrin alphav-beta3 complex. Used to study demyelinating disease and visual epilepsy. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 8700.7) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (104933921..104993317)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (100184039..100201035)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (107494326..107511355)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

All pups with exposure to methadone demonstrated decreased expression of PLP in the cerebral cortex and hippocampus.In the cerebellum, PLP expression was downregulated without apparent alteration of CNP and MBP expression. PLP and MBP expression, but not CNP expression, were significantly inhibited in the brainstem.
Title: Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure.
PLP and DM-20 mRNA expression is restricted to oligodendrocyte-lineage cells
Title: The expression of PLP/DM-20 mRNA is restricted to the oligodendrocyte-lineage cells in the adult rat spinal cord.
Protein levels of PLP were significantly greater in orbital frontal cortex (OFC) but not dorsal striatum (dSTR) of females as compared to males, suggesting that myelination is increased in OFC but similar in dSTR of females as compared to males
Title: Sex differences in myelin-associated protein levels within and density of projections between the orbital frontal cortex and dorsal striatum of adult rats: implications for inhibitory control.
Perinatal methylmercury exposure reduces the expression of Plp1 and Cnp splice variants in cerebellum of rat pups.
Title: Perinatal methylmercury exposure perturbs the expression of Plp1 and Cnp splice variants in cerebellum of rat pups.
PLP localization in the cell membrane is altered in myelination-inhibiting fibronectin substrates.
Title: The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix.
PLP transport to the myelin membrane proceeds via a transcytotic mechanism mediated by sulfatide with a conformational alteration and transient partitioning of PLP into distinct membrane microdomains involved in biosynthetic and transcytotic transport
Title: The major myelin-resident protein PLP is transported to myelin membranes via a transcytotic mechanism: involvement of sulfatide.
Differences in myelin and disparate distributions of myelin protein markers in comparison to wild-type controls are observed in PLP1 transgenic rats.
Title: Characterization of a PLP-overexpressing transgenic rat, a model for the connatal form of Pelizaeus-Merzbacher disease.
Mutation in the myelin proteolipid protein gene alters BK and SK channel function in the caudal medulla.
Title: Mutation in the myelin proteolipid protein gene alters BK and SK channel function in the caudal medulla.
Proteolipid protein gene modulates viability and phenotype of neurons; PLP-specific products contributed to decreased neuron survival.
Title: Proteolipid protein gene modulates viability and phenotype of neurons.
We conclude that an ESE in exon3B regulates PLP 5' donor site selection and that ASF/SF2 protein participates in the regulation of PLP alternative splicing in oligodendrocytes.
Title: PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plp1 (e-PCR), detects polymorphism
- UniSTS:507161

RH141820 (e-PCR)
- UniSTS:223812

D4Ulb4 (e-PCR)
- UniSTS:518994

DXMit9 (e-PCR), detects polymorphism
- UniSTS:132197

D573 (e-PCR)
- UniSTS:124840

PMC311008P1 (e-PCR)
- UniSTS:272836

DXWox26 (e-PCR)
- UniSTS:517828

RH140080 (e-PCR)
- UniSTS:222161

Plp1 (e-PCR), detects polymorphism
- UniSTS:531423

Plp1 (e-PCR), detects polymorphism
- UniSTS:495852

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of myelin sheath	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in AMPA selective glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within astrocyte development	ISO Inferred from Sequence Orthology more info
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon ensheathment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system myelination	ISO Inferred from Sequence Orthology more info
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
part_of integrin alphav-beta3 complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: myelin proteolipid protein

Names: Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); lipophilin; proteolipid protein (myelin) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030990.3 → NP_112252.1 myelin proteolipid protein

See identical proteins and their annotated locations for NP_112252.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P60203, Q561K5

UniProtKB/TrEMBL

A6KNU2

Related

ENSRNOP00000003283.4, ENSRNOT00000003283.7

Conserved Domains (1) summary

pfam01275
Location:5 → 273

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

104933921..104993317

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279812.1 → XP_063135882.1 myelin proteolipid protein isoform X2

UniProtKB/TrEMBL

A0A097BVK2
XM_017601913.3 → XP_017457402.1 myelin proteolipid protein isoform X1

UniProtKB/Swiss-Prot

P60203, Q561K5

UniProtKB/TrEMBL

A6KNU2

Conserved Domains (1) summary

pfam01275
Location:5 → 273

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
XM_017601914.3 → XP_017457403.1 myelin proteolipid protein isoform X2

UniProtKB/TrEMBL

A0A097BVK2

Conserved Domains (1) summary

pfam01275
Location:5 → 238

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
XM_063279808.1 → XP_063135878.1 myelin proteolipid protein isoform X1

UniProtKB/Swiss-Prot

P60203, Q561K5

UniProtKB/TrEMBL

A6KNU2
XM_063279810.1 → XP_063135880.1 myelin proteolipid protein isoform X2

UniProtKB/TrEMBL

A0A097BVK2
XM_063279807.1 → XP_063135877.1 myelin proteolipid protein isoform X1

UniProtKB/Swiss-Prot

P60203, Q561K5

UniProtKB/TrEMBL

A6KNU2
XM_063279811.1 → XP_063135881.1 myelin proteolipid protein isoform X2

UniProtKB/TrEMBL

A0A097BVK2
XM_063279809.1 → XP_063135879.1 myelin proteolipid protein isoform X1

UniProtKB/Swiss-Prot

P60203, Q561K5

UniProtKB/TrEMBL

A6KNU2