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    Nek1 NIMA-related kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290705, updated on 11-Apr-2024

    Summary

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    Symbol
    Nek1provided by RGD
    Full Name
    NIMA-related kinase 1provided by RGD
    Primary source
    RGD:1309375
    See related
    Ensembl:ENSRNOG00000010418 AllianceGenome:RGD:1309375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 14-3-3 protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in cilium assembly; protein phosphorylation; and regulation of DNA damage checkpoint. Predicted to act upstream of or within several processes, including cellular response to DNA damage stimulus; response to ionizing radiation; and spermatogenesis. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asphyxiating thoracic dystrophy; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 79.3), Testes (RPKM 71.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nek1 in Genome Data Viewer
    Location:
    16p12
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (34009092..34137418, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28998229..29125426, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (32321010..32439421, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482542 Neighboring gene SH3 domain containing ring finger 1 Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene chloride voltage-gated channel 3 Neighboring gene chromobox 3 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NEK1 mutations cause short-rib polydactyly syndrome type majewski. Thiel C, et al. Am J Hum Genet, 2011 Jan 7. PMID 21211617, Free PMC Article
    2. Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1. Chen Y, et al. Cell Cycle, 2009 Jan 15. PMID 19158487, Free PMC Article
    3. Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice. Upadhya P, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618398, Free PMC Article
    4. Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control. Chen Y, et al. Cell Cycle, 2008 Oct. PMID 18843199, Free PMC Article
    5. NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases. El Hokayem J, et al. J Med Genet, 2012 Apr. PMID 22499340

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek1
    Names
    NIMA (never in mitosis gene a)-related expressed kinase 1
    NIMA (never in mitosis gene a)-related kinase 1
    NP_001099552.2
    XP_038950287.1
    XP_038950288.1
    XP_038950289.1
    XP_038950290.1
    XP_038950291.1
    XP_038950292.1
    XP_038950293.1
    XP_038950295.1
    XP_038950296.1
    XP_038950297.1
    XP_063131284.1
    XP_063131286.1
    XP_063131287.1
    XP_063131288.1
    XP_063131289.1
    XP_063131290.1
    XP_063131292.1
    XP_063131293.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106082.4 → NP_001099552.2  serine/threonine-protein kinase Nek1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D3ZB99
      Related
      ENSRNOP00000043277.5, ENSRNOT00000043100.6
      Conserved Domains (2) summary
      smart00220
      Location:4 → 258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3 → 258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      34009092..34137418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275222.1 → XP_063131292.1  serine/threonine-protein kinase Nek1 isoform X8

    2. XM_063275218.1 → XP_063131288.1  serine/threonine-protein kinase Nek1 isoform X5

    3. XM_063275216.1 → XP_063131286.1  serine/threonine-protein kinase Nek1 isoform X2

    4. XM_063275214.1 → XP_063131284.1  serine/threonine-protein kinase Nek1 isoform X1

    5. XM_039094360.2 → XP_038950288.1  serine/threonine-protein kinase Nek1 isoform X1

      Conserved Domains (1) summary
      cd08218
      Location:3 → 258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

    6. XM_039094359.2 → XP_038950287.1  serine/threonine-protein kinase Nek1 isoform X1

      Conserved Domains (1) summary
      cd08218
      Location:3 → 258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

    7. XM_063275220.1 → XP_063131290.1  serine/threonine-protein kinase Nek1 isoform X7

    8. XM_063275217.1 → XP_063131287.1  serine/threonine-protein kinase Nek1 isoform X5

    9. XM_063275219.1 → XP_063131289.1  serine/threonine-protein kinase Nek1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZRX9

    10. XM_039094361.2 → XP_038950289.1  serine/threonine-protein kinase Nek1 isoform X2

      Related
      ENSRNOP00000081562.1
      Conserved Domains (1) summary
      cd08218
      Location:3 → 258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

    11. XM_039094362.2 → XP_038950290.1  serine/threonine-protein kinase Nek1 isoform X3

      Conserved Domains (1) summary
      cd08218
      Location:3 → 258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

    12. XM_039094363.2 → XP_038950291.1  serine/threonine-protein kinase Nek1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K5C7
      Related
      ENSRNOP00000073376.2
      Conserved Domains (1) summary
      cd08218
      Location:3 → 258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

    13. XM_039094364.2 → XP_038950292.1  serine/threonine-protein kinase Nek1 isoform X8

      Conserved Domains (1) summary
      cd08218
      Location:3 → 258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

    14. XM_039094365.2 → XP_038950293.1  serine/threonine-protein kinase Nek1 isoform X9

      Conserved Domains (2) summary
      PTZ00121
      Location:120 → 526
      PTZ00121; MAEBL; Provisional
      cl21453
      Location:1 → 51
      PKc_like; Protein Kinases, catalytic domain

    15. XM_063275223.1 → XP_063131293.1  serine/threonine-protein kinase Nek1 isoform X11

    16. XM_039094367.2 → XP_038950295.1  serine/threonine-protein kinase Nek1 isoform X10

    17. XM_039094369.2 → XP_038950297.1  serine/threonine-protein kinase Nek1 isoform X13

    18. XM_039094368.2 → XP_038950296.1  serine/threonine-protein kinase Nek1 isoform X12

    RNA

    1. XR_010058284.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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