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    Ints10 integrator complex subunit 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290679, updated on 22-Mar-2024

    Summary

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    Official Symbol
    Ints10provided by RGD
    Official Full Name
    integrator complex subunit 10provided by RGD
    Primary source
    RGD:1304711
    See related
    Ensembl:ENSRNOG00000055331 AllianceGenome:RGD:1304711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304711
    Summary
    Predicted to be involved in snRNA processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to human INTS10 (integrator complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 148.3), Brain (RPKM 111.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ints10 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (25682818..25735840, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (20915223..20947146, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (22616480..22647315, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene lipoprotein lipase Neighboring gene uncharacterized LOC134482365 Neighboring gene ribosomal protein L10, pseudogene 7 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene splicing factor YJU2-like Neighboring gene uncharacterized LOC120097455

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134416.2 → NP_001127888.1  integrator complex subunit 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      B2RYP7
      Related
      ENSRNOP00000093524.1, ENSRNOT00000106088.1

    2. NM_001428697.1 → NP_001415626.1  integrator complex subunit 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      25682818..25735840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275210.1 → XP_063131280.1  integrator complex subunit 10 isoform X8

    2. XM_039094352.2 → XP_038950280.1  integrator complex subunit 10 isoform X5

      UniProtKB/TrEMBL
      B2RYP7

    3. XM_039094353.2 → XP_038950281.1  integrator complex subunit 10 isoform X6

      UniProtKB/TrEMBL
      B2RYP7
      Related
      ENSRNOP00000075205.2

    4. XM_039094349.2 → XP_038950277.1  integrator complex subunit 10 isoform X2

      UniProtKB/TrEMBL
      B2RYP7

    5. XM_039094355.2 → XP_038950283.1  integrator complex subunit 10 isoform X7

      UniProtKB/TrEMBL
      B2RYP7

    6. XM_039094350.2 → XP_038950278.1  integrator complex subunit 10 isoform X3

      UniProtKB/TrEMBL
      B2RYP7
      Related
      ENSRNOP00000074576.2

    7. XM_039094351.2 → XP_038950279.1  integrator complex subunit 10 isoform X4

      UniProtKB/TrEMBL
      B2RYP7

    8. XM_039094348.2 → XP_038950276.1  integrator complex subunit 10 isoform X1

      UniProtKB/TrEMBL
      B2RYP7

    9. XM_039094357.2 → XP_038950285.1  integrator complex subunit 10 isoform X10

      UniProtKB/TrEMBL
      A6KFJ1

    10. XM_063275212.1 → XP_063131282.1  integrator complex subunit 10 isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version

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