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    Napsa napsin A aspartic peptidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60575, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Napsaprovided by RGD
    Official Full Name
    napsin A aspartic peptidaseprovided by RGD
    Primary source
    RGD:61940
    See related
    Ensembl:ENSRNOG00000019854 AllianceGenome:RGD:61940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kdap
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in membrane protein proteolysis and surfactant homeostasis. Predicted to be located in alveolar lamellar body and extracellular space. Predicted to be active in lysosome. Orthologous to human NAPSA (napsin A aspartic peptidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1553.1), Lung (RPKM 581.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Napsa in Genome Data Viewer
    Location:
    1q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104200967..104213603)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95064726..95077101)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100577497..100589802)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase delta 1, catalytic subunit Neighboring gene nuclear receptor subfamily 1, group H, member 2 Neighboring gene potassium voltage-gated channel subfamily C member 3 Neighboring gene myosin heavy chain 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression and functional characterization of rat napsin. Schauer-Vukasinovic V, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 10858550
    2. Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation. Niderla-Bielińska J, et al. Folia Histochem Cytobiol, 2011. PMID 21744336
    3. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis. Woischnik M, et al. Eur Respir J, 2008 Jun. PMID 18216060
    4. Processing of pulmonary surfactant protein B by napsin and cathepsin H. Ueno T, et al. J Biol Chem, 2004 Apr 16. PMID 14766755
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The level of mRNA for differentiation markers: involucrin, filaggrin, keratinocyte differentiation associated protein and trichohyalin, was studied by RealTime PCR.
      Title: Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in alveolar lamellar body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    napsin-A
    Names
    kidney-derived aspartic protease-like protein
    NP_113858.1
    XP_038944991.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031670.2 → NP_113858.1  napsin-A precursor

      See identical proteins and their annotated locations for NP_113858.1

      Status: VALIDATED

      Source sequence(s)
      BC078790, CB809217
      UniProtKB/TrEMBL
      A6JAR3, F7FL28, Q68G15, Q9QX71
      Related
      ENSRNOP00000026992.5, ENSRNOT00000026992.7
      Conserved Domains (2) summary
      pfam00026
      Location:73 → 397
      Asp; Eukaryotic aspartyl protease
      cl11403
      Location:69 → 395
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104200967..104213603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089063.2 → XP_038944991.1  napsin-A isoform X1

      Conserved Domains (1) summary
      cl11403
      Location:70 → 314
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein Strain
    Heading Accession and Version

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