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    Ilf2 interleukin enhancer binding factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310612, updated on 2-May-2024

    Summary

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    Official Symbol
    Ilf2provided by RGD
    Official Full Name
    interleukin enhancer binding factor 2provided by RGD
    Primary source
    RGD:1305734
    See related
    Ensembl:ENSRNOG00000014154 AllianceGenome:RGD:1305734
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab1-143
    Summary
    Predicted to enable DNA binding activity and double-stranded RNA binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Orthologous to human ILF2 (interleukin enhancer binding factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 235.0), Thymus (RPKM 227.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ilf2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178256927..178268773)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175952174..175971191)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189857587..189877777)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 1 Neighboring gene uncharacterized LOC120101091 Neighboring gene transfer RNA methionine (anticodon CAU) 1 Neighboring gene SNAP-associated protein Neighboring gene chromatin target of PRMT1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NF45 inhibits cardiomyocyte apoptosis following myocardial ischemia-reperfusion injury. Liu X, et al. Pathol Res Pract, 2015 Dec. PMID 26573128
    2. Ilf2 is regulated during meiosis and associated to transcriptionally active chromatin. López-Fernández LA, et al. Mech Dev, 2002 Feb. PMID 11804788
    3. Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity. Satoh M, et al. J Biol Chem, 1999 Dec 3. PMID 10574923
    4. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. Kao PN, et al. J Biol Chem, 1994 Aug 12. PMID 7519613
    5. Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense. Harashima A, et al. Genes Dev, 2010 Dec 1. PMID 21123651, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings establish an anti-apoptotic role of NF45 in response to myocardial ischemia-reperfusion injury
      Title: NF45 inhibits cardiomyocyte apoptosis following myocardial ischemia-reperfusion injury.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    interleukin enhancer-binding factor 2
    Names
    liver regeneration-related protein LRRG031

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393800.1 → NP_001380729.1  interleukin enhancer-binding factor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K368, A0A8I6GKM0, B2RZC6
      Related
      ENSRNOP00000072520.1, ENSRNOT00000077362.2
      Conserved Domains (1) summary
      smart00572
      Location:98 → 338
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      178256927..178268773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047886.1: Suppressed sequence

      Description
      NM_001047886.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TP98.1 GenPept UniProtKB/Swiss-Prot:Q7TP98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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