Galt galactose-1-phosphate uridylyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Galtprovided by RGD
Official Full Name: galactose-1-phosphate uridylyltransferaseprovided by RGD
Primary source: RGD:1306483
See related: Ensembl:ENSRNOG00000014766 AllianceGenome:RGD:1306483
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity. Involved in UDP-glucose catabolic process and galactose metabolic process. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in classic galactosemia. Orthologous to human GALT (galactose-1-phosphate uridylyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 132.0), Kidney (RPKM 126.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (61722871..61726128)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (56927039..56930284)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (58144679..58147946)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neonatal GALT gene replacement offers metabolic and phenotypic correction through early adulthood in a rat model of classic galactosemia.
Title: Neonatal GALT gene replacement offers metabolic and phenotypic correction through early adulthood in a rat model of classic galactosemia.
A pilot study of neonatal GALT gene replacement using AAV9 dramatically lowers galactose metabolites in blood, liver, and brain and minimizes cataracts in GALT-null rat pups.
Title: A pilot study of neonatal GALT gene replacement using AAV9 dramatically lowers galactose metabolites in blood, liver, and brain and minimizes cataracts in GALT-null rat pups.
A galactose-1-phosphate uridylyltransferase-null rat model of classic galactosemia mimics relevant patient outcomes and reveals tissue-specific and longitudinal differences in galactose metabolism.
Title: A galactose-1-phosphate uridylyltransferase-null rat model of classic galactosemia mimics relevant patient outcomes and reveals tissue-specific and longitudinal differences in galactose metabolism.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose binding	IC Inferred by Curator more info	PubMed
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables galactose binding	IC Inferred by Curator more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in UDP-glucose catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in galactose catabolic process via UDP-galactose	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactose catabolic process via UDP-galactose	ISO Inferred from Sequence Orthology more info
involved_in galactose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in galactose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within galactose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in galactose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycolytic process from galactose	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: galactose-1-phosphate uridylyltransferase

Names: UDP-glucose--hexose-1-phosphate uridylyltransferase; gal-1-P uridylyltransferase; galactose-1-phosphate uridyl transferase

NP_001013107.1

EC 2.7.7.12

XP_017448726.1

EC 2.7.7.12

XP_038965368.1

EC 2.7.7.12

XP_038965369.1

EC 2.7.7.12

XP_063143374.1

EC 2.7.7.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013089.2 → NP_001013107.1 galactose-1-phosphate uridylyltransferase

See identical proteins and their annotated locations for NP_001013107.1

Status: PROVISIONAL

Source sequence(s)

BC098756

UniProtKB/Swiss-Prot

P43424, Q4KM61

UniProtKB/TrEMBL

A0A8L2QA97, A6IIX1

Related

ENSRNOP00000019886.5, ENSRNOT00000019886.6

Conserved Domains (1) summary

PRK11720
Location:22 → 366

PRK11720; UDP-glucose--hexose-1-phosphate uridylyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

61722871..61726128

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287304.1 → XP_063143374.1 galactose-1-phosphate uridylyltransferase isoform X1

UniProtKB/TrEMBL

A0A8L2QA97
XM_039109440.2 → XP_038965368.1 galactose-1-phosphate uridylyltransferase isoform X2

Conserved Domains (1) summary

PRK11720
Location:38 → 278

PRK11720; UDP-glucose--hexose-1-phosphate uridylyltransferase
XM_017593237.3 → XP_017448726.1 galactose-1-phosphate uridylyltransferase isoform X3
XM_039109441.2 → XP_038965369.1 galactose-1-phosphate uridylyltransferase isoform X4

Conserved Domains (1) summary

PRK11720
Location:1 → 190

PRK11720; UDP-glucose--hexose-1-phosphate uridylyltransferase