Il33 interleukin 33 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il33provided by RGD
Official Full Name: interleukin 33provided by RGD
Primary source: RGD:1311155
See related: Ensembl:ENSRNOG00000016456 AllianceGenome:RGD:1311155
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311155
Summary: Predicted to enable cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of oligodendrocyte differentiation; and regulation of sensory perception of pain. Located in nucleus. Biomarker of acute myocardial infarction; colon cancer; and diabetes mellitus. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 677.6), Kidney (RPKM 455.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (237115478..237149897)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (227701964..227736374)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (248112611..248147030)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence.
Title: Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence.
Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats.
Title: Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats.
Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.
Title: Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.
IL-33 Participates in the Development of Esophageal Adenocarcinoma.
Title: IL-33 Participates in the Development of Esophageal Adenocarcinoma.
Exploration of potential mechanism of interleukin-33 up-regulation caused by 1,4-naphthoquinone black carbon in RAW264.7 cells.
Title: Exploration of potential mechanism of interleukin-33 up-regulation caused by 1,4-naphthoquinone black carbon in RAW264.7 cells.
Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-alpha through activating ERK, p38 MAPK, and JAK2/STAT3.
Title: Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3.
ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL-33/ST2 axis.
Title: ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL-33/ST2 axis.
Epithelial cells expressed IL-33 to promote degranulation of mast cells through inhibition on ST2/PI3K/mTOR-mediated autophagy in allergic rhinitis.
Title: Epithelial cells expressed IL-33 to promote degranulation of mast cells through inhibition on ST2/PI3K/mTOR-mediated autophagy in allergic rhinitis.
Protective role of IL33 signaling in negative pregnancy outcomes associated with lipopolysaccharide exposure.
Title: Protective role of IL33 signaling in negative pregnancy outcomes associated with lipopolysaccharide exposure.
MicroRNA-547-5p-mediated interleukin-33/suppressor of tumorigenicity 2 signaling underlies the genesis and maintenance of neuropathic pain and is targeted by the therapy with bone marrow stromal cells.
Title: MicroRNA-547-5p-mediated interleukin-33/suppressor of tumorigenicity 2 signaling underlies the genesis and maintenance of neuropathic pain and is targeted by the therapy with bone marrow stromal cells.

Submit: New GeneRIF Correction See all GeneRIFs (29)

General gene information

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Markers

RH127711 (e-PCR)
- UniSTS:211021

BE110958 (e-PCR)
- UniSTS:245345

AW533538 (e-PCR)
- UniSTS:245986

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables interleukin-33 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-33 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of gene expression	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in interleukin-33-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-33-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microglial cell activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in microglial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 1 type immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response to wounding	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of macrophage proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD80 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of CD80 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD86 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of CD86 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MHC class I biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MHC class I biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MHC class II biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular defense response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cellular defense response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-13 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of nitric-oxide synthase biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in type 2 immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of type 2 immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-33

Names: IL-33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014166.2 → NP_001014188.1 interleukin-33

See identical proteins and their annotated locations for NP_001014188.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q66H70

UniProtKB/TrEMBL

A0A096MIT4, A6I0X6

Related

ENSRNOP00000022056.7, ENSRNOT00000022056.8

Conserved Domains (1) summary

pfam15095
Location:5 → 262

IL33; Interleukin 33
NM_001419498.1 → NP_001406427.1 interleukin-33

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q66H70

UniProtKB/TrEMBL

A0A096MIT4, A6I0X6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

237115478..237149897

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084456.2 → XP_038940384.1 interleukin-33 isoform X1

UniProtKB/TrEMBL

A0A096MIT4

Conserved Domains (1) summary

pfam15095
Location:5 → 292

IL33; Interleukin 33
XM_039084466.1 → XP_038940394.1 interleukin-33 isoform X1

UniProtKB/TrEMBL

A0A096MIT4

Conserved Domains (1) summary

pfam15095
Location:5 → 292

IL33; Interleukin 33
XM_063268631.1 → XP_063124701.1 interleukin-33 isoform X2

UniProtKB/Swiss-Prot

Q66H70

UniProtKB/TrEMBL

A0A096MIT4, A6I0X6
XM_063268636.1 → XP_063124706.1 interleukin-33 isoform X2

UniProtKB/Swiss-Prot

Q66H70

UniProtKB/TrEMBL

A0A096MIT4, A6I0X6
XM_039084481.2 → XP_038940409.1 interleukin-33 isoform X1

UniProtKB/TrEMBL

A0A096MIT4

Conserved Domains (1) summary

pfam15095
Location:5 → 292

IL33; Interleukin 33
XM_039084461.2 → XP_038940389.1 interleukin-33 isoform X1

UniProtKB/TrEMBL

A0A096MIT4

Conserved Domains (1) summary

pfam15095
Location:5 → 292

IL33; Interleukin 33
XM_039084473.2 → XP_038940401.1 interleukin-33 isoform X1

UniProtKB/TrEMBL

A0A096MIT4

Conserved Domains (1) summary

pfam15095
Location:5 → 292

IL33; Interleukin 33
XM_039084491.2 → XP_038940419.1 interleukin-33 isoform X2

UniProtKB/Swiss-Prot

Q66H70

UniProtKB/TrEMBL

A0A096MIT4, A6I0X6

Conserved Domains (1) summary

pfam15095
Location:5 → 262

IL33; Interleukin 33