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    Syt12 synaptotagmin 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 191595, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Syt12provided by RGD
    Official Full Name
    synaptotagmin 12provided by RGD
    Primary source
    RGD:621876
    See related
    Ensembl:ENSRNOG00000019306 AllianceGenome:RGD:621876
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Srg1
    Summary
    Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in spontaneous exocytosis of neurotransmitter. Located in presynapse. Colocalizes with synaptic vesicle. Orthologous to human SYT12 (synaptotagmin 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 129.2), Liver (RPKM 16.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Syt12 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211158745..211189780, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201729307..201760192, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219690013..219719359, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 2A Neighboring gene small nucleolar RNA SNORA32 Neighboring gene uncharacterized LOC134483956 Neighboring gene ras homolog family member D Neighboring gene solute carrier family 25 member 5, pseudogene 10 Neighboring gene similar to human chromosome 11 open reading frame 86 Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP. Kaeser-Woo YJ, et al. J Neurosci, 2013 Jun 5. PMID 23739973, Free PMC Article
    2. Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog. Thompson CC. J Neurosci, 1996 Dec 15. PMID 8987811, Free PMC Article
    3. Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. Maximov A, et al. J Cell Biol, 2007 Jan 1. PMID 17190793, Free PMC Article
    4. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spontaneous exocytosis of neurotransmitter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-12
    Names
    synaptotagmin XII
    synaptotagmin-related gene 1 protein
    sytXII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138835.1 → NP_620190.1  synaptotagmin-12

      See identical proteins and their annotated locations for NP_620190.1

      Status: PROVISIONAL

      Source sequence(s)
      U71294
      UniProtKB/Swiss-Prot
      P97610
      UniProtKB/TrEMBL
      A6HYX5
      Related
      ENSRNOP00000026153.3, ENSRNOT00000026152.7
      Conserved Domains (2) summary
      cd08406
      Location:284 → 419
      C2B_Synaptotagmin-12; C2 domain second repeat present in Synaptotagmin 12
      cl14603
      Location:152 → 263
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      211158745..211189780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092039.2 → XP_038947967.1  synaptotagmin-12 isoform X1

      UniProtKB/Swiss-Prot
      P97610
      UniProtKB/TrEMBL
      A6HYX5
      Conserved Domains (2) summary
      cd08406
      Location:284 → 419
      C2B_Synaptotagmin-12; C2 domain second repeat present in Synaptotagmin 12
      cl14603
      Location:152 → 263
      C2; C2 domain

    2. XM_039092090.2 → XP_038948018.1  synaptotagmin-12 isoform X2

      Conserved Domains (2) summary
      cd08406
      Location:169 → 304
      C2B_Synaptotagmin-12; C2 domain second repeat present in Synaptotagmin 12
      cl14603
      Location:37 → 148
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97610.1 GenPept UniProtKB/Swiss-Prot:P97610

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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