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    Mark4 microtubule affinity regulating kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680407, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Mark4provided by RGD
    Official Full Name
    microtubule affinity regulating kinase 4provided by RGD
    Primary source
    RGD:1591792
    See related
    Ensembl:ENSRNOG00000017069 AllianceGenome:RGD:1591792
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase activity and tubulin binding activity. Predicted to be involved in several processes, including positive regulation of cilium assembly; positive regulation of protein localization to centrosome; and regulation of centrosome cycle. Predicted to be located in several cellular components, including dendrite; microtubule cytoskeleton; and midbody. Predicted to be part of gamma-tubulin complex. Predicted to be active in cytoplasm. Orthologous to human MARK4 (microtubule affinity regulating kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 46.2), Testes (RPKM 34.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88203352..88239858, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79075353..79108882, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80335517..80367366, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene kinesin light chain 3 Neighboring gene creatine kinase, M-type Neighboring gene exocyst complex component 3-like 2 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines. Yu W, et al. Hum Mol Genet, 2012 Mar 15. PMID 22156579, Free PMC Article
    2. MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons. Tang EI, et al. Endocrinology, 2022 Oct 11. PMID 35971301, Free PMC Article
    3. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) plays a role in cell cycle progression and cytoskeletal dynamics. Rovina D, et al. Eur J Cell Biol, 2014 Aug-Sep. PMID 25123532
    4. Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis. Tang EI, et al. Spermatogenesis, 2012 Apr 1. PMID 22670221, Free PMC Article
    5. Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4. Schneider A, et al. J Neurochem, 2004 Mar. PMID 15009667

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
      Title: Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
    2. MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
      Title: MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
    3. High MARK4 is associated with Alzheimer's disease.
      Title: A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal anchor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of gamma-tubulin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MAP/microtubule affinity-regulating kinase 4
    NP_001178000.1
    XP_006228534.1
    XP_063129714.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191071.1 → NP_001178000.1  MAP/microtubule affinity-regulating kinase 4

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J8N3, D4A6T9
      Related
      ENSRNOP00000023392.2, ENSRNOT00000023392.6
      Conserved Domains (4) summary
      cd12197
      Location:654 → 752
      MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
      smart00220
      Location:59 → 310
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:328 → 370
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:58 → 310
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      88203352..88239858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228472.5 → XP_006228534.1  MAP/microtubule affinity-regulating kinase 4 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTD8, A0A8I6A623
      Related
      ENSRNOP00000086560.1
      Conserved Domains (3) summary
      smart00220
      Location:59 → 310
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:328 → 370
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:58 → 310
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    2. XM_063273644.1 → XP_063129714.1  MAP/microtubule affinity-regulating kinase 4 isoform X1

      UniProtKB/TrEMBL
      D4A6T9
    Nucleotide Protein Strain
    Heading Accession and Version

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