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    Myg1 MYG1 exonuclease [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300258, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Myg1provided by RGD
    Official Full Name
    MYG1 exonucleaseprovided by RGD
    Primary source
    RGD:1359237
    See related
    Ensembl:ENSRNOG00000013343 AllianceGenome:RGD:1359237
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C12orf10
    Summary
    Predicted to enable nuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Predicted to act upstream of or within locomotory exploration behavior. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MYG1 (MYG1 exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 149.3), Kidney (RPKM 126.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myg1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135335364..135342567)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133456778..133463985)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143929662..143936865)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene extra spindle pole bodies like 1, separase Neighboring gene uncharacterized LOC134479583 Neighboring gene prefoldin subunit 5 Neighboring gene aladin WD repeat nucleoporin Neighboring gene Sp7 transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Promoter polymorphism -119C/G in MYG1 (C12orf10) gene is related to vitiligo susceptibility and Arg4Gln affects mitochondrial entrance of Myg1. Philips MA, et al. BMC Med Genet, 2010 Apr 8. PMID 20377893, Free PMC Article
    2. Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences. Philips MA, et al. Behav Brain Res, 2010 Feb 11. PMID 19818808
    3. Characterization of MYG1 gene and protein: subcellular distribution and function. Philips MA, et al. Biol Cell, 2009 Jun. PMID 19014353
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95325

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within locomotory exploration behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MYG1 exonuclease
    Names
    UPF0160 protein MYG1, mitochondrial
    melanocyte proliferating gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005545.1 → NP_001005545.1  MYG1 exonuclease precursor

      See identical proteins and their annotated locations for NP_001005545.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082112
      UniProtKB/Swiss-Prot
      Q641W2
      Related
      ENSRNOP00000017942.3, ENSRNOT00000017942.7
      Conserved Domains (1) summary
      pfam03690
      Location:46 → 366
      UPF0160; uncharacterized protein family (UPF0160)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135335364..135342567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078940.2 → XP_038934868.1  MYG1 exonuclease isoform X1

      Conserved Domains (1) summary
      pfam03690
      Location:2 → 257
      UPF0160; Uncharacterized protein family (UPF0160)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641W2.1 GenPept UniProtKB/Swiss-Prot:Q641W2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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