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    Evi5 ecotropic viral integration site 5 [ Mus musculus (house mouse) ]

    Gene ID: 14020, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Evi5provided by MGI
    Official Full Name
    ecotropic viral integration site 5provided by MGI
    Primary source
    MGI:MGI:104736
    See related
    Ensembl:ENSMUSG00000011831 AllianceGenome:MGI:104736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NB4S
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within cell division. Predicted to be located in cytosol. Is expressed in several structures, including genitourinary system; liver; lung; paravertebral ganglion; and spleen. Orthologous to human EVI5 (ecotropic viral integration site 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 3.7), placenta adult (RPKM 3.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 52.23 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107892661..108022973, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107744795..107875107, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Gfi1 +5.8 kb enhancer Neighboring gene Gfi1 promoter regions Neighboring gene -8.7 kb enhancer upstream of Gfi1 Neighboring gene growth factor independent 1 transcription repressor Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:108168116-108168348 Neighboring gene predicted gene, 42147 Neighboring gene Gfi1 -35 kb enhancer Neighboring gene STARR-seq mESC enhancer starr_13892 Neighboring gene STARR-seq mESC enhancer starr_13893 Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene predicted gene, 42149 Neighboring gene STARR-positive B cell enhancer ABC_E9017 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene predicted gene, 22270 Neighboring gene ribosomal protein L5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas. Baron BW, et al. Blood Cells Mol Dis, 2014 Jan. PMID 23910958, Free PMC Article
    2. Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Jacob B, et al. Blood, 2010 Feb 25. PMID 20008790, Free PMC Article
    3. Evi-5, a common site of retroviral integration in AKXD T-cell lymphomas, maps near Gfi-1 on mouse chromosome 5. Liao X, et al. J Virol, 1995 Nov. PMID 7474133, Free PMC Article
    4. A new region of synteny between human chromosome 1p22 and mouse chromosome 5. Chelsea DM, et al. Int J Mol Med, 2000 May. PMID 10762661
    5. MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene. Schmidt T, et al. Nucleic Acids Res, 1996 Jul 1. PMID 8692692, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GFI1B, EVI5, MYB are additional mouse genes that cooperate with the human BCL6 gene to promote the development of lymphomas.
      Title: GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas.
    2. Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.
      Title: Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ecotropic viral integration site 5 protein
    Names
    EVI-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378824.1 → NP_001365753.1  ecotropic viral integration site 5 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138666
      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:116 → 324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:348 → 693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001378825.1 → NP_001365754.1  ecotropic viral integration site 5 protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138666
      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:116 → 324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:361 → 670
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. NM_007964.2 → NP_031990.2  ecotropic viral integration site 5 protein isoform 1

      See identical proteins and their annotated locations for NP_031990.2

      Status: VALIDATED

      Source sequence(s)
      AC117574, AC138666, AK134294, BI737814, CN456828, CV557033
      Consensus CDS
      CCDS39198.1
      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      UniProtKB/TrEMBL
      F8VPT6
      Related
      ENSMUSP00000108261.2, ENSMUST00000112642.8
      Conserved Domains (3) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:527 → 674
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:456 → 494
      DUF1129; Protein of unknown function (DUF1129)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      107892661..108022973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534781.3 → XP_006534844.1  ecotropic viral integration site 5 protein isoform X5

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:406 → 709
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_006534776.4 → XP_006534839.1  ecotropic viral integration site 5 protein isoform X1

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:392 → 737
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006534783.5 → XP_006534846.1  ecotropic viral integration site 5 protein isoform X6

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:392 → 737
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_006534780.5 → XP_006534843.1  ecotropic viral integration site 5 protein isoform X4

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:389 → 714
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_006534779.4 → XP_006534842.1  ecotropic viral integration site 5 protein isoform X3

      See identical proteins and their annotated locations for XP_006534842.1

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:116 → 324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:348 → 693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_011249407.4 → XP_011247709.1  ecotropic viral integration site 5 protein isoform X3

      See identical proteins and their annotated locations for XP_011247709.1

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:116 → 324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:348 → 693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_006534777.5 → XP_006534840.1  ecotropic viral integration site 5 protein isoform X2

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:144 → 352
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:376 → 721
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_030254127.2 → XP_030109987.1  ecotropic viral integration site 5 protein isoform X9

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:116 → 324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:362 → 658
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_006534784.4 → XP_006534847.1  ecotropic viral integration site 5 protein isoform X7

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:71 → 279
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:303 → 648
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    10. XM_006534785.5 → XP_006534848.1  ecotropic viral integration site 5 protein isoform X8

      UniProtKB/Swiss-Prot
      P97366, Q3TPQ1
      Conserved Domains (2) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:392 → 737
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. XM_006534786.2 → XP_006534849.1  ecotropic viral integration site 5 protein isoform X10

      UniProtKB/TrEMBL
      E9PWR7
      Related
      ENSMUSP00000114845.2, ENSMUST00000128723.8
      Conserved Domains (2) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:389 → 731
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_011249408.4 → XP_011247710.1  ecotropic viral integration site 5 protein isoform X11

      UniProtKB/TrEMBL
      E9PWR7
      Conserved Domains (2) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:389 → 731
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    13. XM_006534787.4 → XP_006534850.1  ecotropic viral integration site 5 protein isoform X12

      Related
      ENSMUSP00000119196.2, ENSMUST00000138111.8
      Conserved Domains (1) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    14. XM_036164779.1 → XP_036020672.1  ecotropic viral integration site 5 protein isoform X13

      UniProtKB/TrEMBL
      Q3TMK4
      Related
      ENSMUSP00000121761.2, ENSMUST00000124034.8
      Conserved Domains (1) summary
      smart00164
      Location:116 → 324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97366.2 GenPept UniProtKB/Swiss-Prot:P97366

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