Pygl liver glycogen phosphorylase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pyglprovided by MGI
Official Full Name: liver glycogen phosphorylaseprovided by MGI
Primary source: MGI:MGI:97829
See related: Ensembl:ENSMUSG00000021069 AllianceGenome:MGI:97829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables glycogen phosphorylase activity. Acts upstream of or within glycogen metabolic process; necroptotic process; and response to bacterium. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; cranium; sensory organ; and urinary system. Used to study glycogen storage disease VI. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGL (glycogen phosphorylase L). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 115.1), liver E18 (RPKM 102.5) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C2; 12 29.01 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (70237589..70274457, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (70190815..70227683, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice.
Title: Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice.
The in vivo consequences of disrupting the G(L)-phosphorylase a interaction, using a mouse model containing a Tyr284Phe substitution in the phosphorylase a-binding region of the hepatic glycogen-associated protein phosphatase-1 protein, is reported.
Title: Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pygl (e-PCR), detects polymorphism
- UniSTS:546969

Pygl (e-PCR), detects polymorphism
- UniSTS:526054

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables AMP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables SHG alpha-glucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables bile acid binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glucose binding	ISO Inferred from Sequence Orthology more info
enables glycogen phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycogen phosphorylase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables linear malto-oligosaccharide phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables purine nucleobase binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables vitamin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycogen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycogen phosphorylase, liver form

NP_573461.2

EC 2.4.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133198.2 → NP_573461.2 glycogen phosphorylase, liver form

See identical proteins and their annotated locations for NP_573461.2

Status: VALIDATED

Source sequence(s)

AK145989, BY435276

Consensus CDS

CCDS25957.1

UniProtKB/Swiss-Prot

Q3UKJ0, Q9ET01

UniProtKB/TrEMBL

Q91WP9

Related

ENSMUSP00000071231.7, ENSMUST00000071250.13

Conserved Domains (2) summary

cd04300
Location:29 → 827

GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...

TIGR02093
Location:32 → 827

P_ylase; glycogen/starch/alpha-glucan phosphorylases