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    Alox15 arachidonate 15-lipoxygenase [ Mus musculus (house mouse) ]

    Gene ID: 11687, updated on 5-Jan-2022

    Summary

    Official Symbol
    Alox15provided by MGI
    Official Full Name
    arachidonate 15-lipoxygenaseprovided by MGI
    Primary source
    MGI:MGI:87997
    See related
    Ensembl:ENSMUSG00000018924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    12-LO; 15-LOX; L-12LO; Alox12l; 12/15-LO
    Summary
    Enables arachidonate 12(S)-lipoxygenase activity and arachidonate 15-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; phosphatidylethanolamine biosynthetic process; and positive regulation of actin filament polymerization. Acts upstream of or within bone mineralization. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; liver; nose; peritoneal fluid; and respiratory system. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 3.1), ovary adult (RPKM 2.5) and 24 other tissues See more
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    Genomic context

    See Alox15 in Genome Data Viewer
    Location:
    11 B3; 11 42.99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70234973..70279465, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70344147..70390538, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70157649..70165533, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40192 Neighboring gene arachidonate lipoxygenase, epidermal Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene proline, glutamic acid and leucine rich protein 1 Neighboring gene predicted gene 12313

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonate 12(S)-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables arachidonate 12(S)-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arachidonate 12(S)-lipoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables arachidonate 15-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables arachidonate 15-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arachidonate 15-lipoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hepoxilin A3 synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hepoxilin-epoxide hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables linoleate 13S-lipoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in arachidonic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in arachidonic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in arachidonic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in arachidonic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-13 ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepoxilin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in hepoxilin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in linoleic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lipoxin A4 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoxygenase pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lipoxygenase pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipoxygenase pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of adaptive immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylethanolamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of peroxisome proliferator activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polyunsaturated fatty acid lipoxygenase ALOX15
    Names
    12-LOX
    12/15-lipoxygenase
    arachidonate 12-lipoxygenase, leukocyte-type
    arachidonate omega-6 lipoxygenase
    hepoxilin A3 synthase Alox15
    linoleate 13S-lipoxygenase
    NP_033790.3
    XP_006532099.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009660.3NP_033790.3  polyunsaturated fatty acid lipoxygenase ALOX15

      See identical proteins and their annotated locations for NP_033790.3

      Status: VALIDATED

      Source sequence(s)
      AK142371, AL596096, U04331
      Consensus CDS
      CCDS24944.1
      UniProtKB/Swiss-Prot
      P39654
      UniProtKB/TrEMBL
      A2CF88
      Related
      ENSMUSP00000019068.7, ENSMUST00000019068.7
      Conserved Domains (2) summary
      cd01753
      Location:2112
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:202654
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70234973..70279465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532036.5XP_006532099.1  polyunsaturated fatty acid lipoxygenase ALOX15 isoform X1

      See identical proteins and their annotated locations for XP_006532099.1

      Conserved Domains (2) summary
      cd01753
      Location:32142
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:232684
      Lipoxygenase
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