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    Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 55979, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Agpat1provided by MGI
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1932075
    See related
    Ensembl:ENSMUSG00000034254 AllianceGenome:MGI:1932075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1-AGP; 1-AGPAT
    Summary
    Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Acts upstream of or within phosphatidic acid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 284.0), testis adult (RPKM 273.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 18.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34823164..34832392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34604195..34613449)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene STARR-positive B cell enhancer ABC_E45 Neighboring gene ring finger protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E11640 Neighboring gene EGF-like domain 8 Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene RIKEN cDNA 2610029K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34767227-34767451 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34768061-34768244 Neighboring gene proline-rich transmembrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice. Agarwal AK, et al. Endocrinology, 2017 Nov 1. PMID 28973305, Free PMC Article
    2. A role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation. Subauste AR, et al. Differentiation, 2010 Sep-Oct. PMID 20561744, Free PMC Article
    3. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Neschen S, et al. Cell Metab, 2005 Jul. PMID 16054099
    4. cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase. Kume K, et al. Biochem Biophys Res Commun, 1997 Aug 28. PMID 9299423
    5. Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis. Lu B, et al. J Lipid Res, 2005 Nov. PMID 16150824

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Agpat1-/- mice developed widespread disturbances of metabolism, sperm development, and neurologic function resulting from disrupted phospholipid homeostasis. AGPAT1 appears to serve important functions in the physiology of multiple organ systems. The Agpat1-deficient mouse provides an important model in which to study the contribution of phospholipid and triacylglycerol synthesis to physiology and diseases.
      Title: Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice.
    2. observations strongly implicate AGPAT1 in the development of skeletal muscle, specifically to terminal differentiation. These findings are linked to the regulation of actin cytoskeleton
      Title: A role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation.
    3. mtGPAT1 might serve as a novel target for treatment of hepatic steatosis and hepatic insulin resistance and that long chain acyl-CoA's do not mediate fat-induced hepatic insulin resistance in this model.
      Title: Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.
    4. mAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption
      Title: Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
    Names
    1-AGP acyltransferase 1
    1-AGPAT 1
    1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
    Lpaat-alpha
    lysophosphatidic acid acyltransferase alpha
    NP_001156851.1
    NP_001401165.1
    NP_001401166.1
    NP_001401167.1
    NP_001401168.1
    NP_001401169.1
    NP_001401170.1
    NP_001401171.1
    NP_061350.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163379.2 → NP_001156851.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_001156851.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS37590.1
      UniProtKB/Swiss-Prot
      O35083, O35446
      UniProtKB/TrEMBL
      A0A0R4J263
      Related
      ENSMUSP00000048573.9, ENSMUST00000037489.15
      Conserved Domains (1) summary
      cd07989
      Location:66 → 253
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    2. NM_001414236.1 → NP_001401165.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009767
      UniProtKB/TrEMBL
      A0A0R4J263

    3. NM_001414237.1 → NP_001401166.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009767
      UniProtKB/TrEMBL
      A0A0R4J263

    4. NM_001414238.1 → NP_001401167.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009767
      UniProtKB/TrEMBL
      A0A0R4J263
      Related
      ENSMUSP00000134358.2, ENSMUST00000174595.2

    5. NM_001414239.1 → NP_001401168.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009767
      Related
      ENSMUSP00000133441.2, ENSMUST00000174041.8

    6. NM_001414240.1 → NP_001401169.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009767

    7. NM_001414241.1 → NP_001401170.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT009767

    8. NM_001414242.1 → NP_001401171.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT009767

    9. NM_018862.4 → NP_061350.3  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_061350.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS37590.1
      UniProtKB/Swiss-Prot
      O35083, O35446
      UniProtKB/TrEMBL
      A0A0R4J263
      Related
      ENSMUSP00000109776.4, ENSMUST00000114140.10
      Conserved Domains (1) summary
      cd07989
      Location:66 → 253
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34823164..34832392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35083.1 GenPept UniProtKB/Swiss-Prot:O35083

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