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    Tcam1 testicular cell adhesion molecule 1 [ Mus musculus (house mouse) ]

    Gene ID: 75870, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tcam1provided by MGI
    Official Full Name
    testicular cell adhesion molecule 1provided by MGI
    Primary source
    MGI:MGI:1923120
    See related
    Ensembl:ENSMUSG00000020712 AllianceGenome:MGI:1923120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930570F09Rik
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within cell-cell adhesion. Predicted to be integral component of plasma membrane. Is expressed in bladder; heart valve; sensory organ; and skeleton. Orthologous to human TCAM1P (testicular cell adhesion molecule 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 28.2) See more
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    Genomic context

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    Location:
    11 E1; 11 68.89 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106163856..106179563)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106273020..106288737)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 5 Neighboring gene predicted gene, 23645 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106130475-106130662 Neighboring gene STARR-positive B cell enhancer ABC_E598 Neighboring gene STARR-positive B cell enhancer ABC_E3029 Neighboring gene STARR-positive B cell enhancer ABC_E10721 Neighboring gene growth hormone Neighboring gene STARR-seq mESC enhancer starr_30919 Neighboring gene CD79B antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Testis-Specific Long Non-Coding RNA, lncRNA-Tcam1, Regulates Immune-Related Genes in Mouse Male Germ Cells. Kurihara M, et al. Front Endocrinol (Lausanne), 2017. PMID 29163367, Free PMC Article
    2. A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA. Kurihara M, et al. J Mol Biol, 2014 Aug 26. PMID 25020229
    3. Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility. Nalam RL, et al. Mol Cell Endocrinol, 2010 Feb 5. PMID 19766163, Free PMC Article
    4. Structure, expression, and conserved physical linkage of mouse testicular cell adhesion molecule-1 (TCAM-1) gene. Sakatani S, et al. Genome, 2000 Dec. PMID 11195349
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A conserved noncoding sequence (CNS1) located upstream of TCAM1 is a novel enhancer for Tcam1 gene expression.
      Title: A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA.
    2. Data show that TCAM1 is not essential for male fertility or germ cell function in Mus musculus.
      Title: Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testicular cell adhesion molecule 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379686.1 → NP_001366615.1  testicular cell adhesion molecule 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL604045
      UniProtKB/TrEMBL
      Q80X70, Q99NB3
      Conserved Domains (3) summary
      pfam03921
      Location:22 → 107
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cd00096
      Location:109 → 116
      Ig; Ig strand A [structural motif]
      cl11960
      Location:109 → 209
      Ig; Immunoglobulin domain

    2. NM_029467.3 → NP_083743.2  testicular cell adhesion molecule 1 precursor

      See identical proteins and their annotated locations for NP_083743.2

      Status: VALIDATED

      Source sequence(s)
      AK076581, BC050746
      Consensus CDS
      CCDS48959.1
      UniProtKB/TrEMBL
      Q80X70, Q99NB3
      Related
      ENSMUSP00000044757.4, ENSMUST00000044462.4
      Conserved Domains (3) summary
      pfam03921
      Location:22 → 107
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cd00096
      Location:109 → 116
      Ig; Ig strand A [structural motif]
      cl11960
      Location:109 → 209
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106163856..106179563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534399.5 → XP_006534462.1  testicular cell adhesion molecule 1 isoform X1

      UniProtKB/TrEMBL
      Q80X70
      Conserved Domains (2) summary
      pfam03921
      Location:36 → 125
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:123 → 222
      Ig; Immunoglobulin domain

    2. XM_006534401.5 → XP_006534464.1  testicular cell adhesion molecule 1 isoform X3

      UniProtKB/TrEMBL
      Q80X70
      Conserved Domains (2) summary
      pfam03921
      Location:58 → 147
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:145 → 244
      Ig; Immunoglobulin domain

    3. XM_006534400.5 → XP_006534463.1  testicular cell adhesion molecule 1 isoform X2

      See identical proteins and their annotated locations for XP_006534463.1

      UniProtKB/TrEMBL
      Q80X70, Q99NB3
      Conserved Domains (3) summary
      pfam03921
      Location:22 → 107
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cd00096
      Location:109 → 116
      Ig; Ig strand A [structural motif]
      cl11960
      Location:109 → 209
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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