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    Fam234a family with sequence similarity 234, member A [ Mus musculus (house mouse) ]

    Gene ID: 106581, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fam234aprovided by MGI
    Official Full Name
    family with sequence similarity 234, member Aprovided by MGI
    Primary source
    MGI:MGI:2146854
    See related
    Ensembl:ENSMUSG00000024187 AllianceGenome:MGI:2146854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Itfg3
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface. Is expressed in midgut and pancreas. Orthologous to human FAM234A (family with sequence similarity 234 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in duodenum adult (RPKM 177.2), small intestine adult (RPKM 108.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 13.07 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26431673..26463216, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26212692..26244307, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene regulator of G-protein signaling 11 Neighboring gene predicted gene, 23123 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene elongin-C-like Neighboring gene STARR-seq mESC enhancer starr_42121 Neighboring gene STARR-positive B cell enhancer ABC_E5581 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:26389741-26389850 Neighboring gene Luc7-like Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene hemoglobin alpha, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM234A
    Names
    protein ITFG3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206335.2 → NP_001193264.1  protein FAM234A isoform 1

      See identical proteins and their annotated locations for NP_001193264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-3 and 5-7 all encode the same isoform (1).
      Source sequence(s)
      AC126438
      Consensus CDS
      CCDS37512.1
      UniProtKB/Swiss-Prot
      Q3TZ74, Q8C0Z1
      Related
      ENSMUSP00000110639.2, ENSMUST00000114988.8
      Conserved Domains (1) summary
      pfam13360
      Location:130 → 250
      PQQ_2; PQQ-like domain

    2. NM_001357894.2 → NP_001344823.1  protein FAM234A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC126438
      Consensus CDS
      CCDS37512.1
      UniProtKB/Swiss-Prot
      Q3TZ74, Q8C0Z1
      Related
      ENSMUSP00000157219.2, ENSMUST00000234687.2

    3. NM_001374603.1 → NP_001361532.1  protein FAM234A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126438
      UniProtKB/TrEMBL
      F6SQM4

    4. NM_001400249.1 → NP_001387178.1  protein FAM234A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC126438
      UniProtKB/Swiss-Prot
      Q3TZ74, Q8C0Z1
      Related
      ENSMUSP00000157155.2, ENSMUST00000234262.2

    5. NM_001400250.1 → NP_001387179.1  protein FAM234A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC126438
      UniProtKB/Swiss-Prot
      Q3TZ74, Q8C0Z1

    6. NM_001400251.1 → NP_001387180.1  protein FAM234A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC126438
      UniProtKB/Swiss-Prot
      Q3TZ74, Q8C0Z1
      Related
      ENSMUSP00000157032.2, ENSMUST00000234175.2

    7. NM_001400252.1 → NP_001387181.1  protein FAM234A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126438
      UniProtKB/TrEMBL
      F6SQM4
      Related
      ENSMUSP00000115724.3, ENSMUST00000141240.3

    8. NM_001400253.1 → NP_001387182.1  protein FAM234A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126438
      UniProtKB/TrEMBL
      F6SQM4

    9. NM_001400254.1 → NP_001387183.1  protein FAM234A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126438
      UniProtKB/TrEMBL
      F6SQM4

    10. NM_001400255.1 → NP_001387184.1  protein FAM234A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC126438

    11. NM_001400256.1 → NP_001387185.1  protein FAM234A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC126438

    12. NM_207217.5 → NP_997100.1  protein FAM234A isoform 1

      See identical proteins and their annotated locations for NP_997100.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5-7 all encode the same isoform (1).
      Source sequence(s)
      AC126438
      Consensus CDS
      CCDS37512.1
      UniProtKB/Swiss-Prot
      Q3TZ74, Q8C0Z1
      Related
      ENSMUSP00000113418.2, ENSMUST00000118487.8
      Conserved Domains (1) summary
      pfam13360
      Location:130 → 250
      PQQ_2; PQQ-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26431673..26463216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246237.3 → XP_011244539.1  protein FAM234A isoform X1

      See identical proteins and their annotated locations for XP_011244539.1

      UniProtKB/Swiss-Prot
      Q3TZ74, Q8C0Z1
      Conserved Domains (1) summary
      pfam13360
      Location:130 → 250
      PQQ_2; PQQ-like domain

    2. XM_036160242.1 → XP_036016135.1  protein FAM234A isoform X1

      UniProtKB/Swiss-Prot
      Q3TZ74, Q8C0Z1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0Z1.1 GenPept UniProtKB/Swiss-Prot:Q8C0Z1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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