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    Pf4 platelet factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 56744, updated on 5-Jan-2022

    Summary

    Official Symbol
    Pf4provided by MGI
    Official Full Name
    platelet factor 4provided by MGI
    Primary source
    MGI:MGI:1888711
    See related
    Ensembl:ENSMUSG00000029373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cxcl4; Scyb4
    Summary
    Predicted to enable CXCR3 chemokine receptor binding activity; chemokine activity; and heparin binding activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to protozoan. Located in collagen-containing extracellular matrix. Is expressed in several structures, including blood vessel; bone marrow; central nervous system; liver; and yolk sac. Orthologous to several human genes including PF4 (platelet factor 4). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in liver E14 (RPKM 119.8), liver E14.5 (RPKM 114.1) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pf4 in Genome Data Viewer
    Location:
    5; 5 E1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90920294..90921242)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90772435..90773383)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91201461..91202409)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 5 Neighboring gene pro-platelet basic protein Neighboring gene chemokine (C-X-C motif) ligand 3 Neighboring gene chemokine (C-X-C motif) ligand 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables CXCR3 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in leukocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    platelet factor 4
    Names
    C-X-C motif chemokine 4
    PF-4
    chemokine (C-X-C motif) ligand 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019932.4NP_064316.1  platelet factor 4 precursor

      See identical proteins and their annotated locations for NP_064316.1

      Status: VALIDATED

      Source sequence(s)
      AK160040, BC061111, BY794492
      Consensus CDS
      CCDS19416.1
      UniProtKB/Swiss-Prot
      Q9Z126
      UniProtKB/TrEMBL
      Q3TVN6, Q6P8R3
      Related
      ENSMUSP00000031320.7, ENSMUST00000031320.8
      Conserved Domains (1) summary
      cd00273
      Location:41104
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      90920294..90921242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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