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    Pltp phospholipid transfer protein [ Mus musculus (house mouse) ]

    Gene ID: 18830, updated on 5-Jan-2022

    Summary

    Official Symbol
    Pltpprovided by MGI
    Official Full Name
    phospholipid transfer proteinprovided by MGI
    Primary source
    MGI:MGI:103151
    See related
    Ensembl:ENSMUSG00000017754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bpife; OD107
    Summary
    Enables lipid transfer activity. Acts upstream of or within flagellated sperm motility and vitamin E biosynthetic process. Located in extracellular space. Is expressed in dental placode; humerus cartilage condensation; oral epithelium; and tooth epithelium. Used to study dry eye syndrome. Orthologous to human PLTP (phospholipid transfer protein). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Broad expression in lung adult (RPKM 368.4), subcutaneous fat pad adult (RPKM 153.5) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Pltp in Genome Data Viewer
    Location:
    2 H3; 2 85.27 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164681438..164699628, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164839518..164857708, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (164665018..164683208, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 25 Neighboring gene neuralized E3 ubiquitin protein ligase 2 Neighboring gene cathepsin A Neighboring gene RIKEN cDNA 4930445K14 gene Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene predicted gene, 46775

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ceramide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ceramide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cerebroside transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol transfer activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables diacylglyceride transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables diacylglycerol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diacylglycerol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables high-density lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables low-density lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidic acid transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidic acid transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine transfer activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidylcholine transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylethanolamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylethanolamine transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylethanolamine transfer activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidylethanolamine transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylglycerol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylglycerol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylglycerol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol transfer activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phospholipid transfer activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipid transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sphingomyelin transfer activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sphingomyelin transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables very-low-density lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ceramide transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycolipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in high-density lipoprotein particle remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vitamin E biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phospholipid transfer protein
    Names
    lipid transfer protein II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011125.2NP_035255.1  phospholipid transfer protein precursor

      See identical proteins and their annotated locations for NP_035255.1

      Status: VALIDATED

      Source sequence(s)
      AK148330, AK149730, U37226
      Consensus CDS
      CCDS17063.1
      UniProtKB/Swiss-Prot
      P55065
      UniProtKB/TrEMBL
      Q3UE59, Q3UFS5
      Related
      ENSMUSP00000061519.8, ENSMUST00000059954.14
      Conserved Domains (2) summary
      smart00328
      Location:25243
      BPI1; BPI/LBP/CETP N-terminal domain
      pfam02886
      Location:228464
      LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164681438..164699628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159615.1XP_036015508.1  phospholipid transfer protein isoform X1

      Conserved Domains (2) summary
      smart00328
      Location:25243
      BPI1; BPI/LBP/CETP N-terminal domain
      pfam02886
      Location:228464
      LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain
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