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Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25426, updated on 11-Apr-2024

Summary

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Official Symbol: Cyp1b1provided by RGD
Official Full Name: cytochrome P450, family 1, subfamily b, polypeptide 1provided by RGD
Primary source: RGD:2460
See related: Ensembl:ENSRNOG00000040287 AllianceGenome:RGD:2460
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables monooxygenase activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; response to gonadotropin; and response to steroid hormone. Located in nucleus. Biomarker of breast adenocarcinoma and esophagus squamous cell carcinoma. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 5608.0) See more
Orthologs: human mouse all
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Genomic context

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Location:: 6q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (21093927..21103091)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (15342312..15350886)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (2308179..2316739, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-488-3p facilitates wound healing through CYP1B1-mediated Wnt/beta-catenin signaling pathway by targeting MeCP2.
Title: MiR-488-3p facilitates wound healing through CYP1B1-mediated Wnt/β-catenin signaling pathway by targeting MeCP2.
Hippocampal Expression of Cytochrome P450 1B1 in Penetrating Traumatic Brain Injury.
Title: Hippocampal Expression of Cytochrome P450 1B1 in Penetrating Traumatic Brain Injury.
LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner.
Title: LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner.
Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
Title: Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.
Title: Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.
The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu).
Title: The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu).
CYP1A1 and CYP1B1 mRNA expression levels were significantly reduced from day 7 and 10, respectively. These results suggested that CpG island hypermethylation of the CYP1A1 and CYP1B1 promoters regulate the low expression of genes involved in the occurrence of isoniazidinduced liver injury
Title: Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid.
Incense smoke exposure significantly induced the expression of CYP1A1, CYP1A2, and CYP1B1 mRNAs in both lung and liver tissues.
Title: Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke.
The influence of dietary lipids on the ontogeny of XMEs was also evaluated. mRNA and protein levels of phase I (CYP1A1, CYP1A2, and CYP1B1) and phase II (NAD(P)H:quinone acceptor oxidoreductase 1 and GSTP1) enzymes were analyzed.
Title: Ontogeny of the major xenobiotic-metabolizing enzymes expression and the dietary lipids modulatory effect in the rat dimethylbenz(a)anthracene-induced breast cancer model.
Increased oxidative stress generated by CYP1B1 contributes to hypertension.
Title: Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Markers

RH139891 (e-PCR)
- UniSTS:221975

Cyp1b1 (e-PCR), detects polymorphism
- UniSTS:525895

Cyp1b1 (e-PCR), detects polymorphism
- UniSTS:462981

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables estrogen 16-alpha-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in benzene-containing compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in benzene-containing compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular aromatic compound metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular aromatic compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cortisol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to luteinizing hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to progesterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in collagen fibril organization	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within dibenzo-p-dioxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in estrogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in estrogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in ganglion development	IEP Inferred from Expression Pattern more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in membrane lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in membrane lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in membrane lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to 3-methylcholanthrene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to follicle-stimulating hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to indole-3-methanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina vasculature development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retinal blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in retinal blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in retinal blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinal metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in toxin metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within toxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in trabecular meshwork development	IEA Inferred from Electronic Annotation more info
involved_in trabecular meshwork development	ISO Inferred from Sequence Orthology more info
involved_in trabecular meshwork development	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome P450 1B1

Names: CYPIB1; P450RAP; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450RAP; hydroperoxy icosatetraenoate dehydratase

NP_037072.1

EC 1.14.14.1

EC 4.2.1.152

XP_017449535.2

EC 1.14.14.1

EC 4.2.1.152

XP_038967731.1

EC 1.14.14.1

EC 4.2.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012940.2 → NP_037072.1 cytochrome P450 1B1

See identical proteins and their annotated locations for NP_037072.1

Status: PROVISIONAL

Source sequence(s)

U09540

UniProtKB/Swiss-Prot

Q64678

UniProtKB/TrEMBL

A6H9T3

Related

ENSRNOP00000075074.2, ENSRNOT00000084171.2

Conserved Domains (1) summary

cd20675
Location:81 → 518

CYP1B1-like; cytochrome P450 family 1, subfamily B, polypeptide 1 and similar cytochrome P450s

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

21093927..21103091

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111803.2 → XP_038967731.1 cytochrome P450 1B1 isoform X1

UniProtKB/Swiss-Prot

Q64678

UniProtKB/TrEMBL

A6H9T3

Conserved Domains (1) summary

cd20675
Location:81 → 518

CYP1B1-like; cytochrome P450 family 1, subfamily B, polypeptide 1 and similar cytochrome P450s
XM_017594046.3 → XP_017449535.2 cytochrome P450 1B1 isoform X1

UniProtKB/Swiss-Prot

Q64678

UniProtKB/TrEMBL

A6H9T3

Conserved Domains (1) summary

cd20675
Location:81 → 518

CYP1B1-like; cytochrome P450 family 1, subfamily B, polypeptide 1 and similar cytochrome P450s