Cracd capping protein inhibiting regulator of actin dynamics [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cracdprovided by RGD
Official Full Name: capping protein inhibiting regulator of actin dynamicsprovided by RGD
Primary source: RGD:1311575
See related: Ensembl:ENSRNOG00000002139 AllianceGenome:RGD:1311575
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311575
Summary: Predicted to be involved in maintenance of gastrointestinal epithelium and negative regulation of barbed-end actin filament capping. Orthologous to human CRACD (capping protein inhibiting regulator of actin dynamics). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 66.9), Brain (RPKM 48.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (31638328..31874391, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (31284066..31520103, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (33649989..33783794, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141277 (e-PCR)
- UniSTS:223273

RH132249 (e-PCR)
- UniSTS:215532

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in epithelial structure maintenance	ISO Inferred from Sequence Orthology more info
involved_in maintenance of gastrointestinal epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: capping protein-inhibiting regulator of actin dynamics

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427853.1 → NP_001414782.1 capping protein-inhibiting regulator of actin dynamics

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

D4A5F4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

31638328..31874391 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272905.1 → XP_063128975.1 capping protein-inhibiting regulator of actin dynamics isoform X3
XM_039092920.2 → XP_038948848.1 capping protein-inhibiting regulator of actin dynamics isoform X2

Conserved Domains (4) summary

PTZ00121
Location:193 → 640

PTZ00121; MAEBL; Provisional

PTZ00449
Location:971 → 1312

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03307
Location:790 → 1148

PHA03307; transcriptional regulator ICP4; Provisional

pfam15262
Location:51 → 178

DUF4592; Domain of unknown function (DUF4592)
XM_039092919.2 → XP_038948847.1 capping protein-inhibiting regulator of actin dynamics isoform X1

Conserved Domains (3) summary

PTZ00121
Location:193 → 640

PTZ00121; MAEBL; Provisional

PTZ00449
Location:971 → 1315

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

pfam15262
Location:51 → 178

DUF4592; Domain of unknown function (DUF4592)
XM_039092927.2 → XP_038948855.1 capping protein-inhibiting regulator of actin dynamics isoform X4

Conserved Domains (3) summary

PTZ00121
Location:187 → 634

PTZ00121; MAEBL; Provisional

PTZ00449
Location:965 → 1309

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

pfam15262
Location:45 → 172

DUF4592; Domain of unknown function (DUF4592)