Aox1 aldehyde oxidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aox1provided by RGD
Official Full Name: aldehyde oxidase 1provided by RGD
Primary source: RGD:620528
See related: Ensembl:ENSRNOG00000015354 AllianceGenome:RGD:620528
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables aldehyde oxidase activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1376.0), Testes (RPKM 237.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q31

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (67073831..67152980)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (59579621..59658772)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (64929682..65007872)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results supported the possibility that XO/XD and AO can contribute to nitric oxide generation.
Title: Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.
It was shown that show that Nrf2 binds to and strongly activates the rat AOX1 gene.
Title: Aldehyde oxidase 1 gene is regulated by Nrf2 pathway.
Data show that aldehyde oxidase (AO) and xanthine oxidase (XO) activities increased significantly after induction of diabetes.
Title: Aldehyde and xanthine oxidase activities in tissues of streptozotocin-induced diabetic rats: effects of vitamin E and selenium supplementation.
Study of aldehyde oxidase-catalyzed metabolic pathway of phenanthridine using MCR-ALS method.
Title: Study of aldehyde oxidase-catalyzed metabolic pathway of phenanthridine using MCR-ALS method.
AO-catalyzed nitrite reduction can be an important source of NO generation, and its NO production will be further increased by therapeutic administration of nitrite
Title: Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite.
The results indicate that the genetic polymorphism of aldehyde oxidase in Donryu strain rats obeys Mendelian heredity
Title: Heredity mode of genetic polymorphism in aldehyde oxidase activity in Donryu strain rats.
Lack of formation of a dimer protein in Donryu rats leads to loss of catalytic activity possibly due to 377G>A nucleotide substitution. Individual and strain differences in aldehyde oxidase activity in rats could be explained by this 377G>A substitution.
Title: Lack of formation of aldehyde oxidase dimer possibly due to 377G>A nucleotide substitution.
Although diabetes had no impact on liver XO and XDH activity, XDH activity in heart, kidney, and brain was significantly greater in late diabetic rats than in controls.
Title: Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats.
Xanthine oxidase and aldehyde oxidase: a simple procedure for the simultaneous purification from rat liver.
Title: Xanthine oxidase and aldehyde oxidase: a simple procedure for the simultaneous purification from rat liver.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables aldehyde oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde oxidase activity	IEA Inferred from Electronic Annotation more info
enables aldehyde oxidase activity	ISO Inferred from Sequence Orthology more info
enables aldehyde oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables molybdopterin cofactor binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin cofactor binding	ISO Inferred from Sequence Orthology more info
enables molybdopterin cofactor binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: aldehyde oxidase 1

Names: aldehyde oxidase (female form); azaheterocycle hydroxylase 1

NP_062236.3

EC 1.2.3.1

XP_038940067.1

EC 1.2.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019363.4 → NP_062236.3 aldehyde oxidase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q9R240, Q9Z0U5

UniProtKB/TrEMBL

A6IP50

Related

ENSRNOP00000059651.4, ENSRNOT00000068633.5

Conserved Domains (1) summary

TIGR02969
Location:4 → 1333

mam_aldehyde_ox; aldehyde oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

67073831..67152980

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084139.2 → XP_038940067.1 aldehyde oxidase 1 isoform X1

UniProtKB/TrEMBL

A0A8I5Y9M0

Related

ENSRNOP00000077590.1

Conserved Domains (1) summary

TIGR02969
Location:36 → 1316

mam_aldehyde_ox; aldehyde oxidase