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    Orc2 origin recognition complex, subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301430, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Orc2provided by RGD
    Official Full Name
    origin recognition complex, subunit 2provided by RGD
    Primary source
    RGD:1311844
    See related
    Ensembl:ENSRNOG00000012558 AllianceGenome:RGD:1311844
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Orc2l
    Summary
    Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication. Predicted to be located in centrosome; heterochromatin; and nucleoplasm. Predicted to be part of inner kinetochore and nuclear origin of replication recognition complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human ORC2 (origin recognition complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 143.7), Spleen (RPKM 114.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Orc2 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67496097..67532548, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60001631..60038301, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65350630..65387293, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 3 Neighboring gene U2 spliceosomal RNA Neighboring gene NGG1 interacting factor 3 like 1 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene BAF nuclear assembly factor 1, pseudogene 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. Prasanth SG, et al. EMBO J, 2004 Jul 7. PMID 15215892, Free PMC Article
    2. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Dannenberg JH, et al. Genes Dev, 2005 Jul 1. PMID 15998811, Free PMC Article
    3. Cyclin E ablation in the mouse. Geng Y, et al. Cell, 2003 Aug 22. PMID 12941272
    4. ATP-dependent assembly of the human origin recognition complex. Siddiqui K, et al. J Biol Chem, 2007 Nov 2. PMID 17716973
    5. A WD-repeat protein stabilizes ORC binding to chromatin. Shen Z, et al. Mol Cell, 2010 Oct 8. PMID 20932478, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA replication origin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012003.1 → NP_001012003.1  origin recognition complex subunit 2

      See identical proteins and their annotated locations for NP_001012003.1

      Status: PROVISIONAL

      Source sequence(s)
      AB164704
      UniProtKB/Swiss-Prot
      Q75PQ8
      UniProtKB/TrEMBL
      A0A8I5ZNQ6, A6IP72
      Conserved Domains (1) summary
      pfam04084
      Location:254 → 560
      ORC2; Origin recognition complex subunit 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67496097..67532548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244956.5 → XP_006245018.1  origin recognition complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006245018.1

      UniProtKB/Swiss-Prot
      Q75PQ8
      UniProtKB/TrEMBL
      A0A8I5ZNQ6, A6IP72
      Related
      ENSRNOP00000042867.3
      Conserved Domains (1) summary
      pfam04084
      Location:254 → 560
      ORC2; Origin recognition complex subunit 2

    2. XM_017596360.3 → XP_017451849.1  origin recognition complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNQ6
      Conserved Domains (1) summary
      pfam04084
      Location:224 → 530
      ORC2; Origin recognition complex subunit 2

    3. XM_063266944.1 → XP_063123014.1  origin recognition complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNQ6

    4. XM_039083303.2 → XP_038939231.1  origin recognition complex subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      Q75PQ8
      UniProtKB/TrEMBL
      A0A8I5ZNQ6, A6IP72
      Conserved Domains (1) summary
      pfam04084
      Location:254 → 560
      ORC2; Origin recognition complex subunit 2

    5. XM_039083305.2 → XP_038939233.1  origin recognition complex subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      Q75PQ8
      UniProtKB/TrEMBL
      A0A8I5ZNQ6, A6IP72
      Related
      ENSRNOP00000079927.1
      Conserved Domains (1) summary
      pfam04084
      Location:254 → 560
      ORC2; Origin recognition complex subunit 2

    6. XM_039083302.2 → XP_038939230.1  origin recognition complex subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      Q75PQ8
      UniProtKB/TrEMBL
      A0A8I5ZNQ6, A6IP72
      Conserved Domains (1) summary
      pfam04084
      Location:254 → 560
      ORC2; Origin recognition complex subunit 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q75PQ8.1 GenPept UniProtKB/Swiss-Prot:Q75PQ8

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