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    Slc31a2 solute carrier family 31 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298091, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Slc31a2provided by RGD
    Official Full Name
    solute carrier family 31 member 2provided by RGD
    Primary source
    RGD:1307963
    See related
    Ensembl:ENSRNOG00000013631 AllianceGenome:RGD:1307963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cellular copper ion homeostasis. Predicted to act upstream of or within regulation of copper ion transmembrane transport. Predicted to be located in late endosome; membrane; and recycling endosome. Predicted to be active in plasma membrane. Orthologous to human SLC31A2 (solute carrier family 31 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 165.6), Lung (RPKM 67.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (80753589..80764126)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (75738008..75748542)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (78120606..78131111)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350981 Neighboring gene uncharacterized LOC134478995 Neighboring gene FKBP prolyl isomerase family member 15 Neighboring gene solute carrier family 31 member 1 Neighboring gene cell division cycle 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells. Bertinato J, et al. Biochem J, 2008 Feb 1. PMID 17944601
    2. Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. Öhrvik H, et al. Proc Natl Acad Sci U S A, 2013 Nov 12. PMID 24167251, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ctr2 promotes copper uptake at the plasma membrane and plays a role in regulating copper levels in COS-7 cells
      Title: Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124776

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables copper ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within copper ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within copper ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in copper ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intracellular copper ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of copper ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein SLC31A2
    Names
    probable low affinity copper uptake protein 2
    solute carrier family 31 (copper transporter), member 2
    solute carrier family 31 (copper transporters), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033693.2 → NP_001028865.2  protein SLC31A2

      See identical proteins and their annotated locations for NP_001028865.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A3L3, A6J7T6, D4AAE7
      Related
      ENSRNOP00000019379.5, ENSRNOT00000019379.8
      Conserved Domains (1) summary
      pfam04145
      Location:3 → 135
      Ctr; Ctr copper transporter family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      80753589..80764126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109465.2 → XP_038965393.1  protein SLC31A2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3L3
      Related
      ENSRNOP00000085226.1
      Conserved Domains (1) summary
      pfam04145
      Location:15 → 110
      Ctr; Ctr copper transporter family
    Nucleotide Protein Strain
    Heading Accession and Version

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