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    Tmub2 transmembrane and ubiquitin-like domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303567, updated on 2-May-2024

    Summary

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    Official Symbol
    Tmub2provided by RGD
    Official Full Name
    transmembrane and ubiquitin-like domain containing 2provided by RGD
    Primary source
    RGD:1304758
    See related
    Ensembl:ENSRNOG00000020916 AllianceGenome:RGD:1304758
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304758
    Summary
    Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be integral component of membrane. Orthologous to human TMUB2 (transmembrane and ubiquitin like domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 119.1), Kidney (RPKM 109.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmub2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87738662..87743118)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87238543..87242968)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90230428..90234874)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene homologous recombination factor with OB-fold Neighboring gene ankyrin repeat and SOCS box-containing 16 Neighboring gene ataxin 7-like 3 Neighboring gene uncharacterized LOC134480881 Neighboring gene upstream binding transcription factor Neighboring gene solute carrier family 4 member 1 (Diego blood group)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116065

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and ubiquitin-like domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031651.2 → NP_001026821.1  transmembrane and ubiquitin-like domain-containing protein 2

      See identical proteins and their annotated locations for NP_001026821.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085794
      UniProtKB/Swiss-Prot
      Q0P5P8, Q4FZV7
      UniProtKB/TrEMBL
      A0A8I6A9G1, A6HJH8
      Conserved Domains (2) summary
      smart00213
      Location:173 → 240
      UBQ; Ubiquitin homologues
      pfam00240
      Location:191 → 244
      ubiquitin; Ubiquitin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      87738662..87743118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247331.5 → XP_006247393.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9G1, A0A8L2QQ50
      Related
      ENSRNOP00000052057.3
      Conserved Domains (2) summary
      smart00213
      Location:209 → 276
      UBQ; Ubiquitin homologues
      pfam00240
      Location:227 → 280
      ubiquitin; Ubiquitin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZV7.1 GenPept UniProtKB/Swiss-Prot:Q4FZV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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