Matn2 matrilin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Matn2provided by RGD
Official Full Name: matrilin 2provided by RGD
Primary source: RGD:1305353
See related: Ensembl:ENSRNOG00000006060 AllianceGenome:RGD:1305353
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity. Predicted to act upstream of or within neurogenesis and response to axon injury. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Orthologous to human MATN2 (matrilin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 184.9), Heart (RPKM 67.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (67380140..67529767)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (65494996..65644613)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (72985832..73210093)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

matrilin-2 plays the key role in maintaining the survival of oval cell and guarantees its proliferation under various injury factors
Title: Matrilin-2 prevents the TNFα-induced apoptosis of WB-F344 cells via suppressing JNK pathway.
activates the expression of myogenic gene Nfix, and activate myoblast differentiation
Title: Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration.
Hepatic oval cells produce matrilin-2, an extracellular matrix protein, during liver regeneration.
Title: Expression of matrilin-2 in oval cells during rat liver regeneration.

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General gene information

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Markers

RH129452 (e-PCR)
- UniSTS:212758

MARC_10159-10160:996678914:1 (e-PCR)
- UniSTS:267055

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to axon injury	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
part_of matrilin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: matrilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427155.1 → NP_001414084.1 matrilin-2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6GJR4, F1LXS3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

67380140..67529767

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595223.3 → XP_017450712.1 matrilin-2 isoform X1

UniProtKB/TrEMBL

A0A8I6GJR4
XM_039080152.2 → XP_038936080.1 matrilin-2 isoform X2

UniProtKB/TrEMBL

A0A8I5YBE6, A0A8I6GJR4

Related

ENSRNOP00000076610.1

Conserved Domains (4) summary

cd01475
Location:53 → 275

vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...

pfam10393
Location:865 → 907

Matrilin_ccoil; Trimeric coiled-coil oligomerization domain of matrilin

pfam14670
Location:405 → 440

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:651 → 871

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...