Slc25a13 solute carrier family 25 member 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a13provided by RGD
Official Full Name: solute carrier family 25 member 13provided by RGD
Primary source: RGD:1565889
See related: Ensembl:ENSRNOG00000009957 AllianceGenome:RGD:1565889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565889
Summary: Predicted to enable acidic amino acid transmembrane transporter activity; calcium ion binding activity; and identical protein binding activity. Predicted to be involved in several processes, including ATP biosynthetic process; acidic amino acid transport; and malate-aspartate shuttle. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in adult-onset type II citrullinemia and neonatal-onset type II citrullinemia. Orthologous to human SLC25A13 (solute carrier family 25 member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 935.8), Kidney (RPKM 448.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (35145721..35328403, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (34179224..34361912, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (31134165..31757006, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-sulfino-L-alanine: proton, glutamate antiporter activity	IEA Inferred from Electronic Annotation more info
enables 3-sulfino-L-alanine: proton, glutamate antiporter activity	ISO Inferred from Sequence Orthology more info
enables 3-sulfino-L-alanine: proton, glutamate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-glutamate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acidic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables aspartate:glutamate, proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables aspartate:glutamate, proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables aspartate:glutamate, proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in malate-aspartate shuttle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within malate-aspartate shuttle	ISO Inferred from Sequence Orthology more info
involved_in malate-aspartate shuttle	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

Names: calcium-binding mitochondrial carrier protein Aralar2; solute carrier family 25 (aspartate/glutamate carrier), member 13; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13; solute carrier family 25, member 13 (citrin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419624.1 → NP_001406553.1 electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

F1LZW6
NM_001419627.1 → NP_001406556.1 electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I5ZK53

Related

ENSRNOP00000076742.1, ENSRNOT00000115980.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

35145721..35328403 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108599.2 → XP_038964527.1 electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6A972

Related

ENSRNOP00000089641.1

Conserved Domains (1) summary

pfam00153
Location:192 → 284

Mito_carr; Mitochondrial carrier protein
XM_039108600.1 → XP_038964528.1 electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6A972

Conserved Domains (1) summary

pfam00153
Location:192 → 284

Mito_carr; Mitochondrial carrier protein