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    Neurl2 neuralized E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311633, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Neurl2provided by RGD
    Official Full Name
    neuralized E3 ubiquitin protein ligase 2provided by RGD
    Primary source
    RGD:1306409
    See related
    Ensembl:ENSRNOG00000015797 AllianceGenome:RGD:1306409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to act upstream of or within sarcomere organization. Predicted to be located in muscle tendon junction. Predicted to be part of VCB complex. Orthologous to human NEURL2 (neuralized E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 133.2), Heart (RPKM 91.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Neurl2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173985996..173988717, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153566659..153569380, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161296303..161299024, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 8 Neighboring gene zinc finger, SWIM-type containing 3 Neighboring gene zinc finger, SWIM-type containing 1 Neighboring gene spermatogenesis associated 25 Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene phosphorylated CTD interacting factor 1 like 1 Neighboring gene phosphorylated CTD interacting factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. Nastasi T, et al. Dev Cell, 2004 Feb. PMID 14960280
    2. Regulation of notch signaling activity. Schweisguth F. Curr Biol, 2004 Feb 3. PMID 14986688
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of VCB complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in muscle tendon junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuralized-like protein 2
    Names
    neuralized homolog 2
    neuralized-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107802.2 → NP_001101272.1  neuralized-like protein 2

      See identical proteins and their annotated locations for NP_001101272.1

      Status: VALIDATED

      Source sequence(s)
      BC158617
      UniProtKB/TrEMBL
      A6JXC1, B0BMZ0, F7FB77
      Related
      ENSRNOP00000021217.4, ENSRNOT00000021216.6
      Conserved Domains (2) summary
      smart00969
      Location:249 → 285
      SOCS_box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases
      cd12887
      Location:25 → 242
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173985996..173988717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283871.1 → XP_063139941.1  neuralized-like protein 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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