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    Ncoa5 nuclear receptor coactivator 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296372, updated on 9-May-2024

    Summary

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    Official Symbol
    Ncoa5provided by RGD
    Official Full Name
    nuclear receptor coactivator 5provided by RGD
    Primary source
    RGD:1307702
    See related
    Ensembl:ENSRNOG00000017824 AllianceGenome:RGD:1307702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity. Predicted to act upstream of or within glucose homeostasis and negative regulation of insulin receptor signaling pathway. Predicted to be located in actin cytoskeleton and nucleoplasm. Orthologous to human NCOA5 (nuclear receptor coactivator 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 101.8), Lung (RPKM 84.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncoa5 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (174155731..174188862, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153736420..153769838, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161465733..161498951, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350521 Neighboring gene matrix metallopeptidase 9 Neighboring gene solute carrier family 12 member 5 Neighboring gene uncharacterized LOC120101785 Neighboring gene CD40 molecule Neighboring gene cadherin 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Gao S, et al. Cancer Cell, 2013 Dec 9. PMID 24332041, Free PMC Article
    2. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106543.2 → NP_001100013.1  nuclear receptor coactivator 5 isoform 1

      See identical proteins and their annotated locations for NP_001100013.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AVA1, A6JXD4, D3ZEI6
      Related
      ENSRNOP00000024214.4, ENSRNOT00000024214.7
      Conserved Domains (1) summary
      COG0124
      Location:185 → 255
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    2. NM_001430217.1 → NP_001417146.1  nuclear receptor coactivator 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001430218.1 → NP_001417147.1  nuclear receptor coactivator 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      174155731..174188862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104630.2 → XP_038960558.1  nuclear receptor coactivator 5 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AHM9
      Related
      ENSRNOP00000092337.1
      Conserved Domains (1) summary
      COG0124
      Location:185 → 255
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    2. XM_063283394.1 → XP_063139464.1  nuclear receptor coactivator 5 isoform X5

    3. XM_063283392.1 → XP_063139462.1  nuclear receptor coactivator 5 isoform X2

      UniProtKB/TrEMBL
      A6JXD4, D3ZEI6

    4. XM_063283391.1 → XP_063139461.1  nuclear receptor coactivator 5 isoform X1

    5. XM_063283393.1 → XP_063139463.1  nuclear receptor coactivator 5 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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