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    Gramd2b GRAM domain containing 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307288, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Gramd2bprovided by RGD
    Official Full Name
    GRAM domain containing 2Bprovided by RGD
    Primary source
    RGD:1311016
    See related
    Ensembl:ENSRNOG00000015225 AllianceGenome:RGD:1311016
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gramd3; RGD1311016
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in cytoplasmic microtubule. Orthologous to human GRAMD2B (GRAM domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 152.3), Brain (RPKM 75.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gramd2b in Genome Data Viewer
    Location:
    18q11-q12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (52082128..52180056)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (49884014..49981955)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (51492196..51591028)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S9, pseudogene 6 Neighboring gene cofilin 1, pseudogene 3 Neighboring gene uncharacterized LOC120098295 Neighboring gene voltage-dependent anion channel 1, pseudogene 11 Neighboring gene aldehyde dehydrogenase 7 family, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
    2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109479

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GRAM domain-containing protein 2B
    Names
    GRAM domain containing 3
    GRAM domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014011.1 → NP_001014033.1  GRAM domain-containing protein 2B

      See identical proteins and their annotated locations for NP_001014033.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090001
      UniProtKB/Swiss-Prot
      Q5FVG8
      UniProtKB/TrEMBL
      A0A8I5ZT46, A6IX52, A6IX54
      Related
      ENSRNOP00000020570.5, ENSRNOT00000020570.7
      Conserved Domains (1) summary
      cd13220
      Location:135 → 227
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      52082128..52180056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254748.5 → XP_006254810.1  GRAM domain-containing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_006254810.1

      UniProtKB/TrEMBL
      A0A0G2K8Q2, A0A8I5ZT46, A6IX53, A6IX54
      Related
      ENSRNOP00000074694.1
      Conserved Domains (1) summary
      cd13220
      Location:122 → 214
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    2. XM_063277299.1 → XP_063133369.1  GRAM domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6APU9, A6IX55
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVG8.1 GenPept UniProtKB/Swiss-Prot:Q5FVG8

    Gene LinkOut

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