Il19 interleukin 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il19provided by MGI
Official Full Name: interleukin 19provided by MGI
Primary source: MGI:MGI:1890472
See related: Ensembl:ENSMUSG00000016524 AllianceGenome:MGI:1890472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cytokine activity. Involved in negative regulation of low-density lipoprotein particle clearance. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; and reactive oxygen species metabolic process. Predicted to be located in extracellular space. Orthologous to human IL19 (interleukin 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.89 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (130860393..130873194, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (130932656..130945457, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways.
Title: Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways.
Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid.
Title: Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid.
The colonic interleukin-19 aggravates the dextran sodium sulfate/stress-induced comorbidities due to colitis and anxiety.
Title: The colonic interleukin-19 aggravates the dextran sodium sulfate/stress-induced comorbidities due to colitis and anxiety.
Interleukin 19 suppresses RANKL-induced osteoclastogenesis via the inhibition of NF-kappaB and p38MAPK activation and c-Fos expression in RAW264.7 cells.
Title: Interleukin 19 suppresses RANKL-induced osteoclastogenesis via the inhibition of NF-κB and p38MAPK activation and c-Fos expression in RAW264.7 cells.
Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis.
Title: Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis.
IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism.
Title: IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism.
Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment.
Title: Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment.
Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation.
Title: Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation.
Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation.
Title: Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation.
IL-19 is an atheroprotective cytokine which decreases the abundance of HuR, leading to reduced inflammatory mRNA stability in Ldlr knockout mice.
Title: Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis in Il19(-/-)×Ldlr(-/-) Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R).

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of low-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-19

Names: IL-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009940.2 → NP_001009940.1 interleukin-19 isoform 1 precursor

See identical proteins and their annotated locations for NP_001009940.1

Status: VALIDATED

Source sequence(s)

AC165322

Consensus CDS

CCDS15264.1

UniProtKB/Swiss-Prot

Q8CJ70

UniProtKB/TrEMBL

Q14BK1

Related

ENSMUSP00000108084.2, ENSMUST00000112465.2

Conserved Domains (1) summary

cl02501
Location:34 → 167

IL10; Interleukin 10
NM_001355135.1 → NP_001342064.1 interleukin-19 isoform 2

Status: VALIDATED

Source sequence(s)

AC165322

Consensus CDS

CCDS87872.1

UniProtKB/TrEMBL

A0A087WST1

Related

ENSMUSP00000141175.2, ENSMUST00000187916.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

130860393..130873194 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529705.1 → XP_006529768.1 interleukin-19 isoform X1

Conserved Domains (1) summary

cl02501
Location:53 → 182

IL10; Interleukin 10
XM_030255026.1 → XP_030110886.1 interleukin-19 isoform X2

UniProtKB/TrEMBL

A0A087WST1
XM_030255027.1 → XP_030110887.1 interleukin-19 isoform X2

UniProtKB/TrEMBL

A0A087WST1