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    ctss2.1 cathepsin S, ortholog2, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 554157, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ctss2.1provided by ZNC
    Official Full Name
    cathepsin S, ortholog2, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-559
    See related
    Ensembl:ENSDARG00000074656 AllianceGenome:ZFIN:ZDB-GENE-050522-559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ctssb1; zf-a41; ctssb.1; fc38f10; fc47h06; ns:zf-a41; im:6797184; wu:fc38f10; wu:fc47h06; wu:fi17f10; zgc:112226; zgc:112369; zgc:123302
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (29509127..29513434)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (29574504..29578811)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 4b Neighboring gene cathepsin K Neighboring gene cathepsin S, ortholog 2, tandem duplicate 2 Neighboring gene one cut domain, family member, like Neighboring gene HORMA domain containing 1 Neighboring gene endosulfine alpha b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Roles for zebrafish focal adhesion kinase in notochord and somite morphogenesis. Henry CA, et al. Dev Biol, 2001 Dec 15. PMID 11784077
    2. Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge. Dong X, et al. Fish Shellfish Immunol, 2016 Jan. PMID 26626584
    3. Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration. Cadiz Diaz A, et al. Proc Natl Acad Sci U S A, 2022 Jul 26. PMID 35858442, Free PMC Article
    4. Evolutionary History of Cathepsin L (L-like) Family Genes in Vertebrates. Zhou J, et al. Int J Biol Sci, 2015. PMID 26221069, Free PMC Article
    5. Transcriptomics approach to investigate zebrafish heart regeneration. Sleep E, et al. J Cardiovasc Med (Hagerstown), 2010 May. PMID 20179605

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123302

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin S, ortholog2, tandem duplicate 1
    Names
    cathepsin S, b.1
    cathepsin Sb, tandem duplicate 1
    NP_001019580.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024409.2 → NP_001019580.2  cathepsin S, ortholog2, tandem duplicate 1 precursor

      See identical proteins and their annotated locations for NP_001019580.2

      Status: VALIDATED

      Source sequence(s)
      AL954306, BC095788, BI980010, EH449466
      UniProtKB/TrEMBL
      Q3B7H0, Q502A6
      Related
      ENSDARP00000099159.3, ENSDART00000112116.4
      Conserved Domains (3) summary
      PTZ00203
      Location:6 → 324
      PTZ00203; cathepsin L protease; Provisional
      smart00848
      Location:27 → 86
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:115 → 329
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      29509127..29513434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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