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    Etfb electron transferring flavoprotein, beta polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 110826, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Etfbprovided by MGI
    Official Full Name
    electron transferring flavoprotein, beta polypeptideprovided by MGI
    Primary source
    MGI:MGI:106098
    See related
    Ensembl:ENSMUSG00000004610 AllianceGenome:MGI:106098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610009I16Rik; 2810441H06Rik
    Summary
    Predicted to enable electron transfer activity. Involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Is expressed in several structures, including alimentary system; cranium; eye; nervous system; and urinary system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFB (electron transfer flavoprotein subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 182.2), kidney adult (RPKM 139.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 28.25 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43093496..43107224)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43444072..43457800)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lens intrinsic membrane protein 2 Neighboring gene natural killer cell group 7 sequence Neighboring gene STARR-positive B cell enhancer ABC_E9689 Neighboring gene claudin domain containing 2 Neighboring gene microRNA 7051 Neighboring gene predicted gene, 39000 Neighboring gene STARR-positive B cell enhancer ABC_E4923 Neighboring gene V-set and immunoglobulin domain containing 10 like Neighboring gene IgLON family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New protein-protein interactions of mitochondrial connexin 43 in mouse heart. Denuc A, et al. J Cell Mol Med, 2016 May. PMID 26915330, Free PMC Article
    2. Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation. Zhang X, et al. Proc Natl Acad Sci U S A, 2020 Feb 4. PMID 31941714, Free PMC Article
    3. Mouse DNA polymerase delta gene (Pold1) maps to chromosome 7. Goldsby RE, et al. Mamm Genome, 1998 Jan. PMID 9434960
    4. Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria. Rhein VF, et al. J Biol Chem, 2014 Aug 29. PMID 25023281, Free PMC Article
    5. Molecular organization, expression and chromosomal localization of the mouse pronapsin gene. Tatnell PJ, et al. Eur J Biochem, 2000 Dec. PMID 11082205

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic neddylation also enhances ETFA and ETFB expression in adult mice and prevents fasting-induced steatosis and mortality.
      Title: Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation.
    2. The results identify new protein-protein interactions between AIF-Cx43, ETFB-Cx43 and AIF-ETFB as possible players in the regulation of the mitochondrial redox state.
      Title: New protein-protein interactions of mitochondrial connexin 43 in mouse heart.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron transfer activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of electron transfer flavoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial electron transfer flavoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    electron transfer flavoprotein subunit beta
    Names
    beta-ETF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026695.3 → NP_080971.2  electron transfer flavoprotein subunit beta

      See identical proteins and their annotated locations for NP_080971.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AI848359, AK150293, BY292045
      Consensus CDS
      CCDS21171.1
      UniProtKB/Swiss-Prot
      Q810V3, Q9DCW4
      Related
      ENSMUSP00000004729.4, ENSMUST00000004729.5
      Conserved Domains (1) summary
      cd01714
      Location:5 → 210
      ETF_beta; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an ...

    RNA

    1. NR_075104.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA207939, AI848359, BE984117, BY292045

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43093496..43107224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCW4.3 GenPept UniProtKB/Swiss-Prot:Q9DCW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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