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    Mark1 MAP/microtubule affinity regulating kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 226778, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Mark1provided by MGI
    Official Full Name
    MAP/microtubule affinity regulating kinase 1provided by MGI
    Primary source
    MGI:MGI:2664902
    See related
    Ensembl:ENSMUSG00000026620 AllianceGenome:MGI:2664902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emk3; Par-1c; mPar-1c; mKIAA1477; B930025N23Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; phospholipid binding activity; and protein kinase activity. Involved in establishment of mitochondrion localization and regulation of dendrite development. Predicted to be located in cytoskeleton; dendrite; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human MARK1 (microtubule affinity regulating kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 14.7), whole brain E14.5 (RPKM 14.5) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H5; 1 89.26 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (184628621..184732152, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (184896424..184999954, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C130074G19 gene Neighboring gene predicted gene, 34602 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 39728 Neighboring gene STARR-seq mESC enhancer starr_03320 Neighboring gene predicted gene, 34732 Neighboring gene STARR-seq mESC enhancer starr_03321 Neighboring gene predicted gene, 37662 Neighboring gene predicted gene, 34797

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development. Fumoto K, et al. J Cell Sci, 2019 Dec 13. PMID 31719161
    2. Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. Maussion G, et al. Hum Mol Genet, 2008 Aug 15. PMID 18492799
    3. Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate. Krumova P, et al. FASEB J, 2015 Jul. PMID 25854701
    4. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Hezel AF, et al. Mol Cell Biol, 2008 Apr. PMID 18227155, Free PMC Article
    5. Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition. Fumoto K, et al. Development, 2017 Jan 1. PMID 27913639

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that Mark1-mediated fibroblast activation induces AECI flattening and thereby regulates distal lung sacculation.
      Title: Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development.
    2. In vitro kinase assays and metabolic-labeling experiments in living cells confirmed MARK1 as an LRRK2 substrate. Moreover, we also showed that LRRK2 and MARK1 are interacting in eukaryotic cells.
      Title: Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.
    3. Overexpression and silencing of MARK1 resulted in significantly shorter dendrite length in mouse neocortical neurons and modified dendritic transport speed.
      Title: Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1477

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MARK1
    Names
    ELKL motif serine-threonine protein kinase 3
    PAR1 homolog c
    NP_001365805.1
    NP_663490.2
    XP_006497203.1
    XP_006497204.1
    XP_030109398.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378876.1 → NP_001365805.1  serine/threonine-protein kinase MARK1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117826, AC131992
      UniProtKB/TrEMBL
      C9K101
      Conserved Domains (3) summary
      cd12196
      Location:697 → 794
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14072
      Location:59 → 311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:331 → 371
      UBA_like_SF; UBA domain-like superfamily

    2. NM_145515.2 → NP_663490.2  serine/threonine-protein kinase MARK1 isoform 2

      See identical proteins and their annotated locations for NP_663490.2

      Status: VALIDATED

      Source sequence(s)
      AC131992, AK047140, AK173181, BC112400, CJ179387, CX210969
      Consensus CDS
      CCDS35817.1
      UniProtKB/Swiss-Prot
      E9QL17, Q69ZI7, Q8VHJ5
      UniProtKB/TrEMBL
      Q14DQ3
      Related
      ENSMUSP00000027929.5, ENSMUST00000027929.10
      Conserved Domains (3) summary
      cd12196
      Location:696 → 793
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14072
      Location:59 → 311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:331 → 371
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      184628621..184732152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497140.5 → XP_006497203.1  serine/threonine-protein kinase MARK1 isoform X1

      UniProtKB/TrEMBL
      C9K101
      Conserved Domains (3) summary
      cd12196
      Location:682 → 779
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14072
      Location:59 → 311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:331 → 371
      UBA_like_SF; UBA domain-like superfamily

    2. XM_030253538.1 → XP_030109398.1  serine/threonine-protein kinase MARK1 isoform X3

      Conserved Domains (3) summary
      cd12196
      Location:417 → 514
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cl21453
      Location:1 → 32
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:52 → 92
      UBA_like_SF; UBA domain-like superfamily

    3. XM_006497141.5 → XP_006497204.1  serine/threonine-protein kinase MARK1 isoform X2

      UniProtKB/TrEMBL
      Q14DQ3
      Conserved Domains (3) summary
      cd12196
      Location:681 → 778
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14072
      Location:59 → 311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:331 → 371
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHJ5.2 GenPept UniProtKB/Swiss-Prot:Q8VHJ5

    Gene LinkOut

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