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    Gpr87 G protein-coupled receptor 87 [ Mus musculus (house mouse) ]

    Gene ID: 84111, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gpr87provided by MGI
    Official Full Name
    G protein-coupled receptor 87provided by MGI
    Primary source
    MGI:MGI:1934133
    See related
    Ensembl:ENSMUSG00000051431 AllianceGenome:MGI:1934133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human GPR87 (G protein-coupled receptor 87). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 4.8), limb E14.5 (RPKM 1.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 D; 3 29.0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (59086325..59102583, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59178904..59195163, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12-like Neighboring gene STARR-seq mESC enhancer starr_07762 Neighboring gene STARR-seq mESC enhancer starr_07763 Neighboring gene G protein-coupled receptor 171 Neighboring gene purinergic receptor P2Y, G-protein coupled, 14 Neighboring gene RIKEN cDNA F630111L10 gene Neighboring gene STARR-seq mESC enhancer starr_07764 Neighboring gene STARR-seq mESC enhancer starr_07765 Neighboring gene predicted gene, 51434 Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene purinergic receptor P2Y, G-protein coupled 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:59062055-59062302 Neighboring gene STARR-seq mESC enhancer starr_07766

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPR87 promotes renal tubulointerstitial fibrosis by accelerating glycolysis and mitochondrial injury. Cui X, et al. Free Radic Biol Med, 2022 Aug 20. PMID 35843477
    2. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Tabata K, et al. Biochem Biophys Res Commun, 2007 Nov 23. PMID 17905198
    3. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. Wittenberger T, et al. J Mol Biol, 2001 Mar 30. PMID 11273702
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR87 promotes renal tubulointerstitial fibrosis by accelerating glycolysis and mitochondrial injury.
      Title: GPR87 promotes renal tubulointerstitial fibrosis by accelerating glycolysis and mitochondrial injury.
    2. Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y receptors.
      Title: The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 87

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302203.1 → NP_001289132.1  G-protein coupled receptor 87

      See identical proteins and their annotated locations for NP_001289132.1

      Status: VALIDATED

      Source sequence(s)
      AK080394, BB799918
      Consensus CDS
      CCDS79914.1
      UniProtKB/Swiss-Prot
      Q8C4Y7, Q99MT7
      UniProtKB/TrEMBL
      Q059H2
      Related
      ENSMUSP00000143683.2, ENSMUST00000200095.2
      Conserved Domains (2) summary
      pfam00001
      Location:60 → 314
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:57 → 173
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      59086325..59102583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502394.5 → XP_006502457.1  G-protein coupled receptor 87 isoform X1

      UniProtKB/TrEMBL
      Q059H2
      Conserved Domains (1) summary
      cd15969
      Location:34 → 316
      7tmA_GPR87; G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032399.1: Suppressed sequence

      Description
      NM_032399.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript may include intronic sequence at its 5' end.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MT7.2 GenPept UniProtKB/Swiss-Prot:Q99MT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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