Ap2b1 adaptor-related protein complex 2, beta 1 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ap2b1provided by MGI
Official Full Name: adaptor-related protein complex 2, beta 1 subunitprovided by MGI
Primary source: MGI:MGI:1919020
See related: Ensembl:ENSMUSG00000035152 AllianceGenome:MGI:1919020
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AP105B; 1300012O03Rik
Summary: Predicted to enable clathrin binding activity. Involved in clathrin-dependent endocytosis and postsynaptic neurotransmitter receptor internalization. Acts upstream of or within circulatory system development and kidney development. Part of AP-2 adaptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 73.6), CNS E18 (RPKM 36.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 50.3 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83189545..83295861)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83298719..83405035)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the AP-2 complex is not associated with the endocytosed plasma membrane-associated clathrin
Title: The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (2) 1 citation
Targeted (1)
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm143 (e-PCR), detects polymorphism
- UniSTS:141581

AI788979 (e-PCR)
- UniSTS:180277

UniSTS:259407 (e-PCR)
- UniSTS:259407

Ap2b1 (e-PCR), detects polymorphism
- UniSTS:259407

Ap2b1 (e-PCR), detects polymorphism
- UniSTS:259408

MARC_4629-4630:966894533:1 (e-PCR)
- UniSTS:269412

Ap2b1 (e-PCR), detects polymorphism
- UniSTS:506731

Ap2b1 (e-PCR), detects polymorphism
- UniSTS:527250

179H3-T7 (e-PCR), detects polymorphism
- UniSTS:209554

D11Pas16 (e-PCR), detects polymorphism
- UniSTS:209578

D11Pas17 (e-PCR), detects polymorphism
- UniSTS:209579

CLAPB1 (e-PCR)
- UniSTS:266170

AP2B1-1 (e-PCR)
- UniSTS:509951

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in clathrin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in clathrin-dependent endocytosis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor internalization	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of AP-2 adaptor complex	ISO Inferred from Sequence Orthology more info
part_of AP-2 adaptor complex	NAS Non-traceable Author Statement more info	PubMed
part_of clathrin adaptor complex	ISO Inferred from Sequence Orthology more info
part_of clathrin coat	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in extrinsic component of presynaptic endocytic zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of membrane coat	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: AP-2 complex subunit beta

Names: adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptor protein complex AP-2 subunit beta; adaptor-related protein complex 2 subunit beta; beta-2-adaptin; beta-adaptin; beta2-adaptin; clathrin assembly protein complex 2 beta large chain; plasma membrane adaptor HA2/AP2 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035854.2 → NP_001030931.1 AP-2 complex subunit beta isoform a

See identical proteins and their annotated locations for NP_001030931.1

Status: VALIDATED

Source sequence(s)

AK138434, AL603711

Consensus CDS

CCDS25161.1

UniProtKB/TrEMBL

H3BIY9, Q5SWR1

Related

ENSMUSP00000018875.7, ENSMUST00000018875.13

Conserved Domains (4) summary

smart00809
Location:731 → 831

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:840 → 950

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region
NM_027915.3 → NP_082191.1 AP-2 complex subunit beta isoform b

See identical proteins and their annotated locations for NP_082191.1

Status: VALIDATED

Source sequence(s)

AK004975, AK138434, AL603711

Consensus CDS

CCDS25162.1

UniProtKB/Swiss-Prot

Q80XJ4, Q9DBG3

UniProtKB/TrEMBL

H3BIY9

Related

ENSMUSP00000070714.8, ENSMUST00000065692.14

Conserved Domains (4) summary

smart00809
Location:717 → 817

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:826 → 936

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

83189545..83295861

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314772.3 → XP_017170261.1 AP-2 complex subunit beta isoform X1

UniProtKB/TrEMBL

H3BIY9, Q5SWR1

Conserved Domains (4) summary

smart00809
Location:731 → 831

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:840 → 950

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region
XM_006534258.5 → XP_006534321.1 AP-2 complex subunit beta isoform X1

See identical proteins and their annotated locations for XP_006534321.1

UniProtKB/TrEMBL

H3BIY9, Q5SWR1

Related

ENSMUSP00000135445.2, ENSMUST00000176523.2

Conserved Domains (4) summary

smart00809
Location:731 → 831

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:840 → 950

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region
XM_036156996.1 → XP_036012889.1 AP-2 complex subunit beta isoform X1

UniProtKB/TrEMBL

H3BIY9, Q5SWR1

Conserved Domains (4) summary

smart00809
Location:731 → 831

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:840 → 950

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region