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    Jam2 junctional adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619374, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Jam2provided by RGD
    Official Full Name
    junctional adhesion molecule 2provided by RGD
    Primary source
    RGD:1561692
    See related
    Ensembl:ENSRNOG00000042848 AllianceGenome:RGD:1561692
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in several processes, including hematopoietic stem cell migration to bone marrow; leukocyte tethering or rolling; and negative regulation of myelination. Predicted to act upstream of or within negative regulation of cell adhesion. Predicted to be located in several cellular components, including cell surface; cell-cell contact zone; and tight junction. Predicted to be integral component of plasma membrane. Predicted to be part of protein complex involved in cell adhesion. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 308.3), Lung (RPKM 301.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (37316287..37366517)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (23830820..23880071)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24235310..24285279)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene amyloid beta precursor protein Neighboring gene uncharacterized LOC134480962

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. Redmond SA, et al. Neuron, 2016 Aug 17. PMID 27499083, Free PMC Article
    2. Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Johnson-Léger CA, et al. Blood, 2002 Oct 1. PMID 12239159
    3. Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation. Ludwig RJ, et al. J Invest Dermatol, 2005 Nov. PMID 16297198
    4. Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Gliki G, et al. Nature, 2004 Sep 16. PMID 15372036
    5. JAM2 interacts with alpha4beta1. Facilitation by JAM3. Cunningham SA, et al. J Biol Chem, 2002 Aug 2. PMID 12070135

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic stem cell migration to bone marrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lymphocyte aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein complex involved in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein complex involved in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in somatodendritic compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    junctional adhesion molecule B
    Names
    junction adhesion molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034004.1 → NP_001029176.1  junctional adhesion molecule B precursor

      See identical proteins and their annotated locations for NP_001029176.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105305
      UniProtKB/TrEMBL
      A6JL57, F1M065, Q3MHC0
      Related
      ENSRNOP00000049564.6, ENSRNOT00000046973.6
      Conserved Domains (3) summary
      cd00096
      Location:47 → 113
      Ig; Immunoglobulin domain
      smart00408
      Location:148 → 221
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:37 → 131
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      37316287..37366517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088608.2 → XP_038944536.1  junctional adhesion molecule B isoform X1

      UniProtKB/TrEMBL
      A6JL57
      Conserved Domains (2) summary
      cd00096
      Location:38 → 42
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:36 → 132
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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