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    St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291325, updated on 13-Apr-2024

    Summary

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    Official Symbol
    St8sia6provided by RGD
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6provided by RGD
    Primary source
    RGD:1303161
    See related
    Ensembl:ENSRNOG00000064205 AllianceGenome:RGD:1303161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat8f
    Summary
    Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process; glycoprotein metabolic process; and oligosaccharide metabolic process. Predicted to act upstream of or within several processes, including blastocyst hatching; glycolipid biosynthetic process; and protein O-linked glycosylation. Predicted to be located in Golgi apparatus. Predicted to be integral component of membrane. Orthologous to human ST8SIA6 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 23.7), Spleen (RPKM 20.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17q12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (81649866..81847970, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (76740755..76884178, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (80960785..81002830, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene tRNA aspartic acid methyltransferase 1 Neighboring gene vimentin Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene signal transducing adaptor molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of a sixth type of alpha 2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans. Takashima S, et al. J Biol Chem, 2002 Jul 5. PMID 11980897
    2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within carbohydrate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glycolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2,8-sialyltransferase 8F
    Names
    ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6
    alpha 2,8-sialyltransferase
    sialyltransferase 8F (alpha-2, 8-sialyltransferase)
    NP_998789.1
    XP_038951485.1
    XP_038951486.1
    XP_063132323.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213624.2 → NP_998789.1  alpha-2,8-sialyltransferase 8F

      See identical proteins and their annotated locations for NP_998789.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6AV23, A6JM47, Q6ZXC7
      Related
      ENSRNOP00000091997.1, ENSRNOT00000098074.1
      Conserved Domains (1) summary
      pfam00777
      Location:138 → 391
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      81649866..81847970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276253.1 → XP_063132323.1  alpha-2,8-sialyltransferase 8F isoform X1

      UniProtKB/TrEMBL
      A0A8I6AV23, A6JM47, Q6ZXC7

    2. XM_039095558.2 → XP_038951486.1  alpha-2,8-sialyltransferase 8F isoform X3

      Conserved Domains (1) summary
      pfam00777
      Location:1 → 240
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_039095557.2 → XP_038951485.1  alpha-2,8-sialyltransferase 8F isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:133 → 386
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version

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