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    Ndufaf5 NADH:ubiquinone oxidoreductase complex assembly factor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296190, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ndufaf5provided by RGD
    Official Full Name
    NADH:ubiquinone oxidoreductase complex assembly factor 5provided by RGD
    Primary source
    RGD:1309829
    See related
    Ensembl:ENSRNOG00000004784 AllianceGenome:RGD:1309829
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309829
    Summary
    Predicted to enable methyltransferase activity and oxidoreductase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and peptidyl-arginine hydroxylation. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 16. Orthologous to human NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 166.4), Brain (RPKM 149.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q41
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (147961612..147991128)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (127507931..127537477)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (133232412..133261932)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 87 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog Neighboring gene U6 spliceosomal RNA Neighboring gene SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase Neighboring gene mono-ADP ribosylhydrolase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease. Sugiana C, et al. Am J Hum Genet, 2008 Oct. PMID 18940309, Free PMC Article
    2. NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I. Rhein VF, et al. J Biol Chem, 2016 Jul 8. PMID 27226634, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in matrix side of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arginine-hydroxylase NDUFAF5, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5
    probable methyltransferase C20orf7 homolog, mitochondrial
    putative methyltransferase NDUFAF5
    NP_001119843.1
    XP_006235159.1
    XP_038960521.1
    XP_063139410.1
    XP_063139411.1
    XP_063139412.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126371.1 → NP_001119843.1  arginine-hydroxylase NDUFAF5, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001119843.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166551
      UniProtKB/Swiss-Prot
      B2GV71
      UniProtKB/TrEMBL
      A0A8I5ZTK1
      Related
      ENSRNOP00000006412.4, ENSRNOT00000006412.7
      Conserved Domains (2) summary
      TIGR02072
      Location:74 → 310
      BioC; malonyl-acyl carrier protein O-methyltransferase BioC
      pfam08241
      Location:94 → 185
      Methyltransf_11; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      147961612..147991128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235097.5 → XP_006235159.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam08241
      Location:94 → 185
      Methyltransf_11; Methyltransferase domain

    2. XM_063283341.1 → XP_063139411.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6HQM0

    3. XM_063283340.1 → XP_063139410.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6HQM0

    4. XM_039104593.2 → XP_038960521.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6HQM0

    5. XM_063283342.1 → XP_063139412.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6HQM0

    RNA

    1. XR_005501826.2 RNA Sequence

    2. XR_005501827.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2GV71.1 GenPept UniProtKB/Swiss-Prot:B2GV71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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