Car7 carbonic anhydrase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Car7provided by RGD
Official Full Name: carbonic anhydrase 7provided by RGD
Primary source: RGD:1306842
See related: Ensembl:ENSRNOG00000012371 AllianceGenome:RGD:1306842
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ca7
Summary: Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process and regulation of intracellular pH. Predicted to act upstream of or within positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and regulation of chloride transport. Predicted to be located in cytosol. Orthologous to human CA7 (carbonic anhydrase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 42.6), Kidney (RPKM 40.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (435520..444927, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (429063..438478, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (636545..645935, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The capability for synchronous gamma-frequency firing in response to high-frequency stimulation emerges abruptly in the hippocampus at day 12 due to a steep developmental upregulation of intrapyramidal carbonic anhydrase isoform VII.
Title: Carbonic anhydrase isoform VII acts as a molecular switch in the development of synchronous gamma-frequency firing of hippocampal CA1 pyramidal cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cellular pH reduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of chloride transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbonic anhydrase 7

Names: carbonic anhydrase VII

NP_001099635.1

EC 4.2.1.1

XP_006255113.1

EC 4.2.1.1

XP_008770465.1

EC 4.2.1.1

XP_063133905.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106165.1 → NP_001099635.1 carbonic anhydrase 7

See identical proteins and their annotated locations for NP_001099635.1

Status: PROVISIONAL

Source sequence(s)

CH474006

UniProtKB/TrEMBL

A0A8I6AD38, A6JXV1, B2RZ61, F7FEQ2

Related

ENSRNOP00000016521.5, ENSRNOT00000016521.8

Conserved Domains (1) summary

cd03149
Location:27 → 262

alpha_CA_VII; Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

435520..444927 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772243.4 → XP_008770465.1 carbonic anhydrase 7 isoform X1

UniProtKB/TrEMBL

A0A8I6AD38

Conserved Domains (1) summary

cl00012
Location:27 → 230

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
XM_063277835.1 → XP_063133905.1 carbonic anhydrase 7 isoform X3
XM_006255051.5 → XP_006255113.1 carbonic anhydrase 7 isoform X2

UniProtKB/TrEMBL

A0A8I6AD38

Conserved Domains (1) summary

cl00012
Location:1 → 206

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...