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    MGST3 microsomal glutathione S-transferase 3 [ Homo sapiens (human) ]

    Gene ID: 4259, updated on 7-Apr-2024

    Summary

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    Official Symbol
    MGST3provided by HGNC
    Official Full Name
    microsomal glutathione S-transferase 3provided by HGNC
    Primary source
    HGNC:HGNC:7064
    See related
    Ensembl:ENSG00000143198 MIM:604564; AllianceGenome:HGNC:7064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GST-3; GST-III
    Summary
    This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
    Expression
    Ubiquitous expression in heart (RPKM 114.7), fat (RPKM 75.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1q24.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (165631234..165656136)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (164977647..165002573)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (165600471..165625373)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LRRC52 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165565420-165565627 Neighboring gene ribosomal protein S2 pseudogene 10 Neighboring gene tRNA-Lys (anticodon CTT) 13-1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165571612-165571772 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:165599392-165599922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2018 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:165619651-165620850 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165626303-165626469 Neighboring gene aldehyde dehydrogenase 9 family member A1 Neighboring gene ribosomal protein S13 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of prostaglandin 15dPGJ(2) -glutathione and 15dPGJ(2)-cysteine conjugates in macrophages and mast cells via MGST3. Steinmetz-Späh J, et al. J Lipid Res, 2022 Dec. PMID 36370807, Free PMC Article
    2. Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease. Ashbrook DG, et al. BMC Genomics, 2014 Oct 3. PMID 25280473, Free PMC Article
    3. Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians. Thameem F, et al. Hum Genet, 2003 Sep. PMID 12898215
    4. Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily. Jakobsson PJ, et al. Am J Respir Crit Care Med, 2000 Feb. PMID 10673221
    5. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. Jakobsson PJ, et al. J Biol Chem, 1997 Sep 5. PMID 9278457

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Variants in MGST3 are associated with differences inn hippocampus size in both human brain data sets (ENIGMA MRI) and in the BXD family of mice. MGST3 is also statistically associated to genes linked to neurodegenerative disorders, including Parkinson's, Huntington's, and Alzheimer's diseases.
      Title: Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of microsomal glutathione S-transferase 3 (MGST3) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables leukotriene-C4 synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arachidonic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukotriene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in prostanoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase 3, mitochondrial
    Names
    LTC4 synthase MGST3
    glutathione peroxidase MGST3
    microsomal GST-3
    microsomal GST-III
    microsomal glutathione S-transferase III
    NP_004519.1
    XP_047276986.1
    XP_054192641.1
    XP_054192642.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004528.4 → NP_004519.1  glutathione S-transferase 3, mitochondrial

      See identical proteins and their annotated locations for NP_004519.1

      Status: REVIEWED

      Source sequence(s)
      AI591182, AL356441, AL451074, BC000505
      Consensus CDS
      CCDS1249.1
      UniProtKB/Swiss-Prot
      B2R592, O14880, Q6ICN4
      UniProtKB/TrEMBL
      Q53GB9
      Related
      ENSP00000356864.3, ENST00000367889.8
      Conserved Domains (1) summary
      pfam01124
      Location:11 → 130
      MAPEG; MAPEG family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      165631234..165656136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421030.1 → XP_047276986.1  glutathione S-transferase 3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q5VV89
      Related
      ENSP00000356860.1, ENST00000367885.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      164977647..165002573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336666.1 → XP_054192641.1  glutathione S-transferase 3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q5VV89

    2. XM_054336667.1 → XP_054192642.1  glutathione S-transferase 3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q5VV89
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14880.1 GenPept UniProtKB/Swiss-Prot:O14880

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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