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    Cds1 CDP-diacylglycerol synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 74596, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cds1provided by MGI
    Official Full Name
    CDP-diacylglycerol synthase 1provided by MGI
    Primary source
    MGI:MGI:1921846
    See related
    Ensembl:ENSMUSG00000029330 AllianceGenome:MGI:1921846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4833409J18Rik
    Summary
    Predicted to enable phosphatidate cytidylyltransferase activity. Involved in lipid droplet formation and positive regulation of fat cell differentiation. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 48.2), duodenum adult (RPKM 46.8) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E5; 5 48.93 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (101913001..101971724)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (101765093..101823858)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430085M18 gene Neighboring gene STARR-seq mESC enhancer starr_13743 Neighboring gene predicted gene, 42134 Neighboring gene STARR-seq mESC enhancer starr_13745 Neighboring gene STARR-positive B cell enhancer mm9_chr5:102222626-102222927 Neighboring gene STARR-seq mESC enhancer starr_13749 Neighboring gene STARR-seq mESC enhancer starr_13750 Neighboring gene STARR-seq mESC enhancer starr_13751 Neighboring gene WD repeat and FYVE domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_13753 Neighboring gene STARR-seq mESC enhancer starr_13754 Neighboring gene predicted gene, 42135 Neighboring gene STARR-seq mESC enhancer starr_13755 Neighboring gene STARR-seq mESC enhancer starr_13758 Neighboring gene predicted gene, 42136

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2. Inglis-Broadgate SL, et al. Gene, 2005 Aug 15. PMID 16023307
    2. CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Qi Y, et al. J Lipid Res, 2016 May. PMID 26946540, Free PMC Article
    3. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. Lykidis A, et al. J Biol Chem, 1997 Dec 26. PMID 9407135
    4. Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. Volta M, et al. Genomics, 1999 Jan 1. PMID 9889000
    5. FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Araujo DJ, et al. Genes Dev, 2015 Oct 15. PMID 26494785, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cds1 showed a very restricted expression pattern and was mapped to chromosome 5E3.
      Title: Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate cytidylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CDP-diacylglycerol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidate cytidylyltransferase 1
    Names
    CDP-DAG synthase 1
    CDP-DG synthase 1
    CDP-diglyceride pyrophosphorylase 1
    CDP-diglyceride synthase 1
    CDS 1
    CTP:phosphatidate cytidylyltransferase 1
    NP_001404788.1
    NP_001404789.1
    NP_775546.2
    XP_006535326.1
    XP_006535327.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417859.1 → NP_001404788.1  phosphatidate cytidylyltransferase 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC121983, AC171108, AC172745

    2. NM_001417860.1 → NP_001404789.1  phosphatidate cytidylyltransferase 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC121983, AC172745

    3. NM_173370.4 → NP_775546.2  phosphatidate cytidylyltransferase 1 isoform a

      See identical proteins and their annotated locations for NP_775546.2

      Status: VALIDATED

      Source sequence(s)
      AC121983, AC171108, AC172745
      Consensus CDS
      CCDS19472.1
      UniProtKB/Swiss-Prot
      P98191, Q8CGZ1
      Related
      ENSMUSP00000031273.9, ENSMUST00000031273.9
      Conserved Domains (1) summary
      cl21502
      Location:123 → 457
      CTP_transf_1; Cytidylyltransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      101913001..101971724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535264.3 → XP_006535327.1  phosphatidate cytidylyltransferase 1 isoform X2

      Conserved Domains (1) summary
      cl21502
      Location:123 → 377
      CTP_transf_1; Cytidylyltransferase family

    2. XM_006535263.4 → XP_006535326.1  phosphatidate cytidylyltransferase 1 isoform X1

      Conserved Domains (1) summary
      cl21502
      Location:123 → 400
      CTP_transf_1; Cytidylyltransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98191.2 GenPept UniProtKB/Swiss-Prot:P98191

    Gene LinkOut

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