Scd2 stearoyl-Coenzyme A desaturase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scd2provided by RGD
Official Full Name: stearoyl-Coenzyme A desaturase 2provided by RGD
Primary source: RGD:621177
See related: Ensembl:ENSRNOG00000046005 AllianceGenome:RGD:621177
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Scd
Summary: Enables stearoyl-CoA 9-desaturase activity. Involved in myelination and response to fatty acid. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 3323.4), Adrenal (RPKM 2026.4) and 8 other tissues See more
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Genomic context

Location:: 1q54

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (253118377..253131436)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (243169171..243182231)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (264059374..264072433)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering beta-cells more susceptible to saturated FA-induced ER stress and apoptosis.
Title: Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.
testicular distribution of Delta5- and Delta6-desaturase and stearoyl-CoA desaturase 1 and 2 shows that all four desaturases seem to be localized in the Sertoli cells, with far lower expression in germ cells
Title: Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis.

Submit: New GeneRIF Correction

General gene information

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Markers

BE107760 (e-PCR)
- UniSTS:247045

M26270 (e-PCR)
- UniSTS:124950

AU050019 (e-PCR)
- UniSTS:146455

RH143783 (e-PCR)
- UniSTS:233029

AU027774 (e-PCR)
- UniSTS:112978

RH140028 (e-PCR)
- UniSTS:222110

RH133521 (e-PCR)
- UniSTS:216804

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-CoA 9-desaturase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyl-CoA 9-desaturase activity	ISO Inferred from Sequence Orthology more info
enables stearoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IEA Inferred from Electronic Annotation more info
enables stearoyl-CoA 9-desaturase activity	ISO Inferred from Sequence Orthology more info
enables stearoyl-CoA 9-desaturase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in monounsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in monounsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in myelination	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: stearoyl-CoA desaturase 2

Names: acyl-CoA desaturase 2; delta(9)-desaturase 2; fatty acid desaturase 2; stearoyl-CoA desaturase (delta-9-desaturase)

NP_114029.1

EC 1.14.19.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031841.2 → NP_114029.1 stearoyl-CoA desaturase 2

See identical proteins and their annotated locations for NP_114029.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q64066, Q6P7B9, Q9JMC9

UniProtKB/TrEMBL

A6JHF6, M0RDU8

Related

ENSRNOP00000067809.1, ENSRNOT00000075397.2

Conserved Domains (2) summary

cd03505
Location:99 → 336

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:101 → 305

FA_desaturase; Fatty acid desaturase