Prkacb protein kinase cAMP-activated catalytic subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkacbprovided by RGD
Official Full Name: protein kinase cAMP-activated catalytic subunit betaprovided by RGD
Primary source: RGD:1310574
See related: Ensembl:ENSRNOG00000004978 AllianceGenome:RGD:1310574
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cAMP-dependent protein kinase activity. Involved in negative regulation of meiotic cell cycle; protein phosphorylation; and response to clozapine. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 561.4), Adrenal (RPKM 229.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (238297140..238389317, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (235636878..235726928, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (252602197..252691886, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

c-Rel is a reasonable phosphorylation target of PKA-Cbeta; the transcriptional activity of c-Rel is stimulated by PKA-Cbeta possibly through the interaction with p300/CBP
Title: Stimulation of c-Rel transcriptional activity by PKA catalytic subunit beta.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF417257 (e-PCR)
- UniSTS:249673

RH133906 (e-PCR)
- UniSTS:217189

X61434 (e-PCR)
- UniSTS:125826

RH139283 (e-PCR)
- UniSTS:221369

Prkacb (e-PCR), detects polymorphism
- UniSTS:507858

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cAMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase A regulatory subunit binding	IC Inferred by Curator more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of meiotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary base	IEA Inferred from Electronic Annotation more info
located_in ciliary base	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cAMP-dependent protein kinase catalytic subunit beta

Names: PKA C-beta; protein kinase, cAMP dependent, catalytic, beta; protein kinase, cAMP-dependent, beta catalytic subunit

NP_001071113.1

EC 2.7.11.11

XP_006233513.1

EC 2.7.11.11

XP_006233514.1

EC 2.7.11.11

XP_006233515.1

EC 2.7.11.11

XP_038957812.2

EC 2.7.11.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077645.1 → NP_001071113.1 cAMP-dependent protein kinase catalytic subunit beta

See identical proteins and their annotated locations for NP_001071113.1

Status: PROVISIONAL

Source sequence(s)

D10770

UniProtKB/Swiss-Prot

P68182

UniProtKB/TrEMBL

A0A8I6GBC1, A6HWE9

Related

ENSRNOP00000062228.1, ENSRNOT00000068739.2

Conserved Domains (1) summary

cd14209
Location:42 → 331

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

238297140..238389317 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233451.5 → XP_006233513.1 cAMP-dependent protein kinase catalytic subunit beta isoform X1

See identical proteins and their annotated locations for XP_006233513.1

UniProtKB/TrEMBL

A0A8I6A4F6, A0A8I6GBC1, A6HWF0

Related

ENSRNOP00000086804.1

Conserved Domains (2) summary

PTZ00263
Location:79 → 398

PTZ00263; protein kinase A catalytic subunit; Provisional

cd14209
Location:89 → 378

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
XM_006233452.5 → XP_006233514.1 cAMP-dependent protein kinase catalytic subunit beta isoform X2

See identical proteins and their annotated locations for XP_006233514.1

UniProtKB/TrEMBL

A0A8I6GBC1, A6HWF1

Related

ENSRNOP00000085004.1

Conserved Domains (1) summary

cd14209
Location:30 → 319

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
XM_006233453.5 → XP_006233515.1 cAMP-dependent protein kinase catalytic subunit beta isoform X3

See identical proteins and their annotated locations for XP_006233515.1

UniProtKB/TrEMBL

A0A8I6AV42, A6HWF2, Q05759

Related

ENSRNOP00000092040.1

Conserved Domains (1) summary

cd14209
Location:29 → 318

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
XM_039101884.2 → XP_038957812.2 cAMP-dependent protein kinase catalytic subunit beta isoform X4