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    Myadm myeloid-associated differentiation marker [ Rattus norvegicus (Norway rat) ]

    Gene ID: 369016, updated on 3-Apr-2024

    Summary

    Official Symbol
    Myadmprovided by RGD
    Official Full Name
    myeloid-associated differentiation markerprovided by RGD
    Primary source
    RGD:727835
    See related
    Ensembl:ENSRNOG00000053450 AllianceGenome:RGD:727835
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including negative regulation of heterotypic cell-cell adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein kinase C signaling. Predicted to be located in cortical actin cytoskeleton; membrane raft; and ruffle. Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human MYADM (myeloid associated differentiation marker). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 206.2), Heart (RPKM 195.9) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Myadm in Genome Data Viewer
    Location:
    1q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74779616..74796752, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65864180..65874701, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64438465..64448332, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691003 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 7 Neighboring gene protein kinase C, gamma Neighboring gene ribosomal protein L17, pseudogene 11 Neighboring gene olfactory receptor family 6 subfamily A member L1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    NOT involved_in cell-cell junction maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane raft organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane raft organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of heterotypic cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase C signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myeloid-associated differentiation marker
    Names
    myeloid up-regulated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183332.1NP_899161.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_899161.1

      Status: PROVISIONAL

      Source sequence(s)
      AY344060
      UniProtKB/Swiss-Prot
      Q6VBQ5
      Related
      ENSRNOP00000095076.1, ENSRNOT00000117211.1
      Conserved Domains (1) summary
      pfam01284
      Location:162309
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      74779616..74796752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228035.5XP_006228097.1  myeloid-associated differentiation marker isoform X1

      See identical proteins and their annotated locations for XP_006228097.1

      UniProtKB/TrEMBL
      A0A0G2K8C4, A6KS43, Q05BA4
      Related
      ENSRNOP00000074552.1
      Conserved Domains (1) summary
      pfam01284
      Location:162309
      MARVEL; Membrane-associating domain
    2. XM_039085873.2XP_038941801.1  myeloid-associated differentiation marker isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8C4, A6KS43, Q05BA4
      Related
      ENSRNOP00000094663.1
      Conserved Domains (1) summary
      pfam01284
      Location:162309
      MARVEL; Membrane-associating domain
    3. XM_063270027.1XP_063126097.1  myeloid-associated differentiation marker isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8C4, A6KS43, Q05BA4