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    Arl4a ADP-ribosylation factor like GTPase 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29308, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Arl4aprovided by RGD
    Official Full Name
    ADP-ribosylation factor like GTPase 4Aprovided by RGD
    Primary source
    RGD:2152
    See related
    Ensembl:ENSRNOG00000069300 AllianceGenome:RGD:2152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arl4
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARL4A (ADP ribosylation factor like GTPase 4A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 215.8), Spleen (RPKM 101.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arl4a in Genome Data Viewer
    Location:
    6q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (62809287..62811297, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (57079496..57084156, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (59945926..59950586, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10, pseudogene 21 Neighboring gene 60S ribosomal protein L29-like Neighboring gene prohibitin 2, pseudogene 3 Neighboring gene scinderin Neighboring gene leucine-rich single-pass membrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108709

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 4A
    Names
    ADP-ribosylation factor-like 4
    ADP-ribosylation factor-like 4A
    ADP-ribosylation-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019186.1 → NP_062059.1  ADP-ribosylation factor-like protein 4A

      See identical proteins and their annotated locations for NP_062059.1

      Status: PROVISIONAL

      Source sequence(s)
      X77235
      UniProtKB/Swiss-Prot
      P61214
      UniProtKB/TrEMBL
      A6HBC6
      Related
      ENSRNOP00000084810.1, ENSRNOT00000108440.1
      Conserved Domains (1) summary
      cd04152
      Location:18 → 200
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      62809287..62811297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240051.4 → XP_006240113.1  ADP-ribosylation factor-like protein 4A isoform X1

      See identical proteins and their annotated locations for XP_006240113.1

      UniProtKB/Swiss-Prot
      P61214
      UniProtKB/TrEMBL
      A6HBC6
      Related
      ENSRNOP00000089325.1
      Conserved Domains (1) summary
      cd04152
      Location:18 → 200
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    2. XM_006240052.5 → XP_006240114.1  ADP-ribosylation factor-like protein 4A isoform X1

      See identical proteins and their annotated locations for XP_006240114.1

      UniProtKB/Swiss-Prot
      P61214
      UniProtKB/TrEMBL
      A6HBC6
      Conserved Domains (1) summary
      cd04152
      Location:18 → 200
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61214.1 GenPept UniProtKB/Swiss-Prot:P61214

    Gene LinkOut

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