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    Usp32 ubiquitin specific peptidase 32 [ Mus musculus (house mouse) ]

    Gene ID: 237898, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Usp32provided by MGI
    Official Full Name
    ubiquitin specific peptidase 32provided by MGI
    Primary source
    MGI:MGI:2144475
    See related
    Ensembl:ENSMUSG00000000804 AllianceGenome:MGI:2144475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900074J03Rik; 6430526O11Rik
    Summary
    Predicted to enable thiol-dependent deubiquitinase. Predicted to be located in cytosol; plasma membrane; and recycling endosome. Predicted to be active in Golgi apparatus. Is expressed in choroid plexus; cranial ganglion; and dorsal root ganglion. Orthologous to several human genes including USP32 (ubiquitin specific peptidase 32). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 14.5), liver E14.5 (RPKM 12.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 C; 11 51.34 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84875263..85031107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84984437..85140281, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917 Neighboring gene carbonic anhydrase 4 Neighboring gene STARR-positive B cell enhancer ABC_E5257 Neighboring gene STARR-seq mESC enhancer starr_30231 Neighboring gene STARR-seq mESC enhancer starr_30232 Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial pseudogene Neighboring gene ribosomal protein L13, pseudogene 1 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30233 Neighboring gene STARR-positive B cell enhancer ABC_E7034 Neighboring gene STARR-seq mESC enhancer starr_30234 Neighboring gene CHD1 helical C-terminal domain containing 1 Neighboring gene predicted gene, 23506 Neighboring gene amyloid beta precursor protein binding protein 2 Neighboring gene predicted gene, 51947

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers. Akhavantabasi S, et al. Mamm Genome, 2010 Aug. PMID 20549504
    2. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Wang T, et al. Cell, 2017 Feb 23. PMID 28162770, Free PMC Article
    3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    4. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 32
    Names
    deubiquitinating enzyme 32
    ubiquitin specific protease 32
    ubiquitin thioesterase 32
    ubiquitin-specific-processing protease 32
    NP_001025105.1
    XP_011247292.1
    XP_011247293.1
    XP_030101829.1
    XP_030101830.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029934.1 → NP_001025105.1  ubiquitin carboxyl-terminal hydrolase 32

      See identical proteins and their annotated locations for NP_001025105.1

      Status: VALIDATED

      Source sequence(s)
      AL596183, AL669859, BC058994
      Consensus CDS
      CCDS36264.1
      UniProtKB/Swiss-Prot
      F8VPZ3, Q3US74, Q6PD17, Q7TT84, Q8CCP4
      Related
      ENSMUSP00000103710.3, ENSMUST00000108075.9
      Conserved Domains (6) summary
      COG5560
      Location:518 → 1316
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:237 → 293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:1225 → 1565
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:519 → 586
      DUSP; DUSP domain
      pfam13499
      Location:236 → 293
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:623 → 710
      Ubiquitin_3; Ubiquitin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      84875263..85031107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245970.1 → XP_030101830.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

      Conserved Domains (3) summary
      COG5126
      Location:148 → 298
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:477 → 1275
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:1193 → 1523
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_011248990.1 → XP_011247292.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

      Conserved Domains (3) summary
      COG5126
      Location:189 → 339
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:518 → 1330
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:1248 → 1578
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_030245969.2 → XP_030101829.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

      Conserved Domains (3) summary
      COG5126
      Location:148 → 298
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:477 → 1289
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:1207 → 1537
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. XM_011248991.1 → XP_011247293.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

      Conserved Domains (2) summary
      COG5126
      Location:189 → 339
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:518 → 910
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F8VPZ3.1 GenPept UniProtKB/Swiss-Prot:F8VPZ3

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