Ddr1 discoidin domain receptor family, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddr1provided by MGI
Official Full Name: discoidin domain receptor family, member 1provided by MGI
Primary source: MGI:MGI:99216
See related: Ensembl:ENSMUSG00000003534 AllianceGenome:MGI:99216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cak; Nep; PTK3A; CD167a; 6030432F18
Summary: Enables collagen binding activity. Involved in several processes, including smooth muscle cell migration; smooth muscle cell-matrix adhesion; and wound healing, spreading of cells. Acts upstream of or within several processes, including collagen-activated tyrosine kinase receptor signaling pathway; mammary gland development; and neuron projection development. Located in plasma membrane. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; mammary gland; and retina. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human DDR1 (discoidin domain receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 32.9), colon adult (RPKM 31.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.7 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35992459..36015633, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35681567..35704741, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development.
Title: DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development.
Euphorbia factor L1 suppresses breast cancer liver metastasis via DDR1-mediated immune infiltration.
Title: Euphorbia factor L1 suppresses breast cancer liver metastasis via DDR1-mediated immune infiltration.
Evidence That DDR1 Promotes Oligodendrocyte Differentiation during Development and Myelin Repair after Injury.
Title: Evidence That DDR1 Promotes Oligodendrocyte Differentiation during Development and Myelin Repair after Injury.
Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer.
Title: Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer.
DDR1 activation in macrophage promotes IPF by regulating NLRP3 inflammasome and macrophage reaction.
Title: DDR1 activation in macrophage promotes IPF by regulating NLRP3 inflammasome and macrophage reaction.
Deficiency in DDR1 Induces Pulmonary Hypertension and Impaired Alveolar Development.
Title: Deficiency in DDR1 Induces Pulmonary Hypertension and Impaired Alveolar Development.
Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.
Title: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.
Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
Title: Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis.
Title: Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis.
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis.
Title: DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Gene trapped (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI323681 (e-PCR)
- UniSTS:180998

RH46779 (e-PCR)
- UniSTS:66537

D6S2203 (e-PCR)
- UniSTS:66538

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables collagen binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase collagen receptor activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen-activated tyrosine kinase receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female pregnancy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lactation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
NOT involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: epithelial discoidin domain-containing receptor 1

Names: CD167 antigen-like family member A; cell adhesion kinase; discoidin receptor tyrosine kinase; epithelial discoidin domain receptor 1; protein-tyrosine kinase MPK-6; tyrosine kinase DDR; tyrosine-protein kinase CAK

NP_001185760.1

EC 2.7.10.1

NP_001185762.1

EC 2.7.10.1

NP_001411562.1

EC 2.7.10.1

NP_001411564.1

EC 2.7.10.1

NP_001411566.1

EC 2.7.10.1

NP_001411568.1

EC 2.7.10.1

NP_001411569.1

EC 2.7.10.1

NP_001411570.1

EC 2.7.10.1

NP_031610.1

EC 2.7.10.1

NP_766550.1

EC 2.7.10.1

XP_006523598.1

EC 2.7.10.1

XP_006523599.1

EC 2.7.10.1

XP_006523600.1

EC 2.7.10.1

XP_011244561.1

EC 2.7.10.1

XP_030105324.1

EC 2.7.10.1

XP_036016169.1

EC 2.7.10.1

XP_036016171.1

EC 2.7.10.1

XP_036016172.1

EC 2.7.10.1

XP_036016173.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198831.1 → NP_001185760.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001185760.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).

Source sequence(s)

AK143088, BC037108, CK790776, L57509

Consensus CDS

CCDS28703.1

UniProtKB/Swiss-Prot

Q03146

UniProtKB/TrEMBL

O35407

Related

ENSMUSP00000133047.3, ENSMUST00000166980.9

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:602 → 905

PKc_like; Protein Kinases, catalytic domain
NM_001198833.1 → NP_001185762.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001185762.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).

Source sequence(s)

AK143088, BC037108, BY062785, L57509

Consensus CDS

CCDS28703.1

UniProtKB/Swiss-Prot

Q03146

UniProtKB/TrEMBL

O35407

Related

ENSMUSP00000113062.2, ENSMUST00000119825.8

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:602 → 905

PKc_like; Protein Kinases, catalytic domain
NM_001424633.1 → NP_001411562.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CR974483

UniProtKB/Swiss-Prot

Q03146
NM_001424635.1 → NP_001411564.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CR974483

UniProtKB/Swiss-Prot

Q03146
NM_001424637.1 → NP_001411566.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CR974483

UniProtKB/TrEMBL

Q544T2
NM_001424639.1 → NP_001411568.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CR974483

UniProtKB/TrEMBL

Q544T2
NM_001424640.1 → NP_001411569.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CR974483

UniProtKB/TrEMBL

Q544T2
NM_001424641.1 → NP_001411570.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CR974483

UniProtKB/TrEMBL

Q544T2
NM_007584.3 → NP_031610.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_031610.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).

Source sequence(s)

AK143088, BC037108, L57509

Consensus CDS

CCDS28703.1

UniProtKB/Swiss-Prot

Q03146

UniProtKB/TrEMBL

O35407

Related

ENSMUSP00000112570.2, ENSMUST00000117301.8

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:602 → 905

PKc_like; Protein Kinases, catalytic domain
NM_172962.2 → NP_766550.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_766550.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, and encodes a shorter isoform (2) than isoform 1.

Source sequence(s)

CR974483

Consensus CDS

CCDS37603.1

UniProtKB/TrEMBL

O35407, Q544T2

Related

ENSMUSP00000094945.4, ENSMUST00000097333.10

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:565 → 868

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

35992459..36015633 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523536.4 → XP_006523599.1 epithelial discoidin domain-containing receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006523599.1

UniProtKB/Swiss-Prot

Q03146

UniProtKB/TrEMBL

O35407

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:602 → 905

PKc_like; Protein Kinases, catalytic domain
XM_030249464.2 → XP_030105324.1 epithelial discoidin domain-containing receptor 1 isoform X2

UniProtKB/TrEMBL

O35407, Q544T2

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:565 → 868

PKc_like; Protein Kinases, catalytic domain
XM_006523537.3 → XP_006523600.1 epithelial discoidin domain-containing receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006523600.1

UniProtKB/Swiss-Prot

Q03146

UniProtKB/TrEMBL

O35407

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:602 → 905

PKc_like; Protein Kinases, catalytic domain
XM_036160276.1 → XP_036016169.1 epithelial discoidin domain-containing receptor 1 isoform X2

UniProtKB/TrEMBL

O35407, Q544T2

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:565 → 868

PKc_like; Protein Kinases, catalytic domain
XM_006523535.5 → XP_006523598.1 epithelial discoidin domain-containing receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006523598.1

UniProtKB/Swiss-Prot

Q03146

UniProtKB/TrEMBL

O35407

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:602 → 905

PKc_like; Protein Kinases, catalytic domain
XM_036160280.1 → XP_036016173.1 epithelial discoidin domain-containing receptor 1 isoform X2

UniProtKB/TrEMBL

O35407, Q544T2

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:565 → 868

PKc_like; Protein Kinases, catalytic domain
XM_036160279.1 → XP_036016172.1 epithelial discoidin domain-containing receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q03146

UniProtKB/TrEMBL

O35407

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:602 → 905

PKc_like; Protein Kinases, catalytic domain
XM_036160278.1 → XP_036016171.1 epithelial discoidin domain-containing receptor 1 isoform X2

UniProtKB/TrEMBL

O35407, Q544T2

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:565 → 868

PKc_like; Protein Kinases, catalytic domain
XM_011246259.3 → XP_011244561.1 epithelial discoidin domain-containing receptor 1 isoform X1

See identical proteins and their annotated locations for XP_011244561.1

UniProtKB/Swiss-Prot

Q03146

UniProtKB/TrEMBL

O35407

Conserved Domains (2) summary

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:602 → 905

PKc_like; Protein Kinases, catalytic domain