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    Fuca2 fucosidase, alpha-L- 2, plasma [ Mus musculus (house mouse) ]

    Gene ID: 66848, updated on 18-Apr-2024

    Summary

    Official Symbol
    Fuca2provided by MGI
    Official Full Name
    fucosidase, alpha-L- 2, plasmaprovided by MGI
    Primary source
    MGI:MGI:1914098
    See related
    Ensembl:ENSMUSG00000019810 AllianceGenome:MGI:1914098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610025O11Rik; 5530401P20Rik
    Summary
    Predicted to enable alpha-L-fucosidase activity. Predicted to be involved in several processes, including fucose metabolic process; glycoside catabolic process; and regulation of entry of bacterium into host cell. Predicted to be located in extracellular space. Predicted to be active in lysosome. Is expressed in nervous system and respiratory system. Orthologous to human FUCA2 (alpha-L-fucosidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 23.4), heart adult (RPKM 17.8) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    10 A2; 10 4.86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13376314..13394779)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13500570..13519035)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25812 Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene phosphatase and actin regulator 2 Neighboring gene predicted gene, 46211 Neighboring gene STARR-seq mESC enhancer starr_25813 Neighboring gene STARR-seq mESC enhancer starr_25814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene adenosine deaminase, tRNA-specific 2 Neighboring gene RIKEN cDNA A730010A20 gene Neighboring gene STARR-seq mESC enhancer starr_25816 Neighboring gene androgen-induced 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-L-fucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha-L-fucosidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycoside catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of entry of bacterium into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    plasma alpha-L-fucosidase
    Names
    alpha-L-fucoside fucohydrolase 2
    NP_001317127.1
    NP_080075.2
    XP_006512890.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330198.1NP_001317127.1  plasma alpha-L-fucosidase isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC153979, AK017443, AK030320
      Consensus CDS
      CCDS23701.1
      UniProtKB/Swiss-Prot
      Q8VEM3, Q99KR8, Q9D7Z8, Q9DCL7
      UniProtKB/TrEMBL
      Q505Q3
      Related
      ENSMUSP00000055519.6, ENSMUST00000060212.13
      Conserved Domains (2) summary
      smart00812
      Location:24407
      Alpha_L_fucos; Alpha-L-fucosidase
      pfam16757
      Location:370455
      Fucosidase_C; Alpha-L-fucosidase C-terminal domain
    2. NM_025799.5NP_080075.2  plasma alpha-L-fucosidase isoform a precursor

      See identical proteins and their annotated locations for NP_080075.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC153979, AI841078, AK030320, CK343852
      Consensus CDS
      CCDS23701.1
      UniProtKB/Swiss-Prot
      Q8VEM3, Q99KR8, Q9D7Z8, Q9DCL7
      UniProtKB/TrEMBL
      Q505Q3
      Related
      ENSMUSP00000113499.3, ENSMUST00000121465.3
      Conserved Domains (2) summary
      smart00812
      Location:24407
      Alpha_L_fucos; Alpha-L-fucosidase
      pfam16757
      Location:370455
      Fucosidase_C; Alpha-L-fucosidase C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      13376314..13394779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512827.4XP_006512890.1  plasma alpha-L-fucosidase isoform X1

      See identical proteins and their annotated locations for XP_006512890.1

      UniProtKB/Swiss-Prot
      Q8VEM3, Q99KR8, Q9D7Z8, Q9DCL7
      UniProtKB/TrEMBL
      Q505Q3
      Conserved Domains (2) summary
      smart00812
      Location:24407
      Alpha_L_fucos; Alpha-L-fucosidase
      pfam16757
      Location:370455
      Fucosidase_C; Alpha-L-fucosidase C-terminal domain